lncRNA is a non-coding RNA transcript, with a length that is greater than 200 nt, which can regulate gene expression at multiple levels [8]. Numerous studies have shown that lncRNA participates in multiple processes of HCC tumogenesis and development [9–11]. lncRNA MALAT1 (metastasis-...
a Those coding for both HBV and HCV fall into the group with HBV. Rate of MALO and Its Components The incidence rate (95% CI) of MALO was lower in PLWH (5.1/1000 PY, 95% CI 4.2–6.1) compared to patients without HIV (13.1/1000 PY, 95% CI 12.9–13.3). The rate of MALO was ...
identified a long non-coding RNA (SMIM30) that binds to ribosomal protein S6 (RPS6), which regulates cell proliferation and migration to promote HCC devel- opment [39]. Han et al. found that adhesive junction- associated protein 1 (AJAP1) oversubscription restrained tumor initiation and ...
ultimately leading to improved survival outcomes. Benefiting from the recent advancements in tumor treatment, neoadjuvant therapy has been gradually recommended by major guidelines for certain types of malignant tumors
The emerging role of microRNAs and long noncoding RNAs in drug resistance of hepatocellular carcinoma. Mol Cancer. 2019;18(1):147. doi:10.1186/s12943-019-1086-z 57. Cheng J, Chen Y, Zhao P, et al. Downregulation of miRNA-638 promotes angiogenesis and growth of hepatocellular carcinoma by...
Circular RNAs (circRNAs), a specific series of noncoding RNAs with covalently closed, single-stranded structures and lacking a 5’ cap and 3’ poly(A) tail4, have long been considered “waste” produced during RNA splicing. In recent years, a large number of circRNAs in mammalian cells have...
miRs are short non-coding nucleic acids with 18–24 nucleo- tides found within cells and circulating in the blood [5]. miR-21 is a key player in various types of liver disease, including alcoholic liver disease, non-alcoholic fatty liver disease, fibrosis and HCC [6, 7]. It was ...
Epigenetic mechanisms such as DNA methylation (for example in TSGs like p16, RASSF1A or SYK), histone modifications (for example demethylation of H3 on lysine 4) and non-coding RNAs regulation, lncRNA (XIST, HOTAIR, AIR and KCNQ1OT) and miRNA (oncogenic: miR-221, miR-9 and miR23b; ...
and adapters were subsequently ligated to the resulting double-stranded cDNA fragments. The coding regions of the transcriptome were then captured from this library using sequence-specific probes to create the final library. Paired-end 150 bp sequencing was conducted using the Illumina Novaseq6000 pl...
long non-coding RNA small nucleolar RNA host gene 1 microRNA-376a FOXK1 Snail Introduction It has been estimated that liver cancer is the fourth most deadly cancer in the world in 2018.1 Hepatocellular carcinoma (HCC) is the most frequent type of liver cancer. Many risk factors have been ...