The emerging role of microRNAs and long noncoding RNAs in drug resistance of hepatocellular carcinoma. Mol Cancer. 2019;18(1):147. doi:10.1186/s12943-019-1086-z 57. Cheng J, Chen Y, Zhao P, et al. Downregulation of miRNA-638 promotes angiogenesis and growth of hepatocellular carcinoma by...
While genetic factors play a role in almost every disease, it is important to note that weight-loss surgery leads to improvement and/or resolution of NASH in approximately 80% of patients (Clark and Diehl, 2003), suggesting that environmental factors may dominate over genetic factors in this ...
SGLT2 is overexpressed in HCC (Du et al., 2022), and the administration of SGLT1 inhibitors showed promising results in decreased HCC cell proliferation and tumour growth, concomitant with the improvement of liver function (Hendryx et al., 2022). Curiously, and because SGLT2 inhibitors were ...
An improvement in NAS by ≥2 points without an increase in fibrosis stage (NCT04501406) was considered the target to be achieved. Regardless, pioglitazone can only be used to treat patients with NAFLD if they have biopsy-proven NASH based on 2018 AASLD practice guidelines [92]. The clinical ...
An improvement in NAS by ≥2 points without an increase in fibrosis stage (NCT04501406) was considered the target to be achieved. Regardless, pioglitazone can only be used to treat patients with NAFLD if they have biopsy-proven NASH based on 2018 AASLD practice guidelines [92]. The clinical ...