Full Name hemoglobin, beta Calculated Molecular Weight 147 aa, 16 kDa Observed Molecular Weight 13-16 kDa GenBank Accession Number BC007075 Gene Symbol HBB Gene ID (NCBI) 3043 RRID AB_10598329 Conjugate Unconj
BMC Medical Genetics (2016) 17:75 DOI 10.1186/s12881-016-0334-y TECHNICAL ADVANCE Open Access Rapid detection of pathological mutations and deletions of the haemoglobin beta gene (HBB) by High Resolution Melting (HRM) analysis and Gene Ratio Analysis Copy Enumeration PCR (GRACE-PCR) Andrew ...
Full size image We employed the OP9 co-culture system to induce the hematopoietic differentiation of β-thalassemia iPSCs before and after gene correction. The morphologies of the TALENs-corrected iPSCs and the parental lines changed rapidly upon differentiation in OP9 co-culture (Supplementary Figur...
codon 5 [−CT] (HBB: c.17_18delCT) mutation in beta-globin (β-globin) gene and δ0 codon 59 [−A] (HBD: c.179delA) mutation in delta-globin (δ-globin) gene. The proband tested negative for the common deletional forms of alpha thalassemia (α-thal). Polymorphism of the Xm...