反应实例 T3P was dosed to a mixture of acid, amine, and pyridine in 2:1 v/v MeCN/EtOAc. This solvent ratio, upon quenching with 0.5 M aqueous HCl, provided the direct-drop crystallization of free base amide 112 (34.1 kg, 88% yield) ...
反应实例 T3P was dosed to a mixture of acid, amine, and pyridine in 2:1 v/v MeCN/EtOAc. This solvent ratio, upon quenching with 0.5 M aqueous HCl, provided the direct-drop crystallization of free base amide 112 (34.1 kg, 88% yield) with high purity (>99% achiral, 0.5% ent-112) ...
A substitution reaction between intermediates 142 and 148 in the presence of Cs2CO3 under a nitrogen atmosphere gave intermediate 162 which was subjected to deprotection to afford amine 163. Amide bond formation between amine 163 and acid 152 employing standard peptide coupling conditions yielded 164, ...
Objective: The objective of this work is to achieve a one pot synthesis of diamide using various coupling reagents. Method: Straightforward one-pot coupling of dicarboxylic acid with corresponding amine was accomplished in the presence of HATU under ambient condition using 2-Me THF as an industrial...
Product Categories: peptides;carboxylic ester;Coupling Reagent;Peptide Coupling Reagents;Miscellaneous Reagents;HATU;Peptide coupling agents;Pharmaceutical Intermediates;Amino Acid Derivatives;PROTECTED AMINO ACID & PEPTIDES;Peptide;intermediate;148893-10-1 ...
Such reactions are typically performed in two distinct reaction steps: (1) reaction of a carboxylic acid with HATU to form the OAt-active ester; then (2) addition of the nucleophile (e.g., alcohol or amine) to the active ester solution to afford the acylated product. In the first step...
HATU(1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate) is a reagent used inpeptide couplingchemistry to generate an active ester from a carboxylic acid. HATU can be used along with Hünig's base(N,N-diisopropylethylamine, DIPEA) to form amide ...
T3P was dosed to a mixture of acid, amine, and pyridine in 2:1 v/v MeCN/EtOAc. This solvent ratio, upon quenching with 0.5 M aqueous HCl, provided the direct-drop crystallization of free base amide 112 (34.1 kg, 88% yield) with high ...
HATU[148893-10-1] is a coupling reagent and used as an additive in peptide synthesis. It is also involved efficiently to speed up the coupling process and reduces the loss of chiral integrity. Reagent for: Synthesis of Aurora A kinase inhibitors, HPLC assay to determine D- and L- acid en...