An Efficient Protocol for Acid-Amine Coupling using T3P as Coupling AgentArpit C. RadadiaJaydip G. RajparaRajendra JadavYogesh T. Naliapara
In this method, 2 mmol of 2-formylbenzoic acid dissolved in ethyl acetate and then amine (2 mmol), trialkyl phosphite (or diethyl phosphite) (2 mmol) and T3P® (1.5 mmol in 1.8 mL of in EtOAc) were added to the pervious mixture and refluxed for 3 h. Existence electron-withdrawing ...
Alcohol functionality can be then transformed into a suitable leaving group, such as but not limited to Cl or OMs, using conditions known to a person skilled in the art. The addition of amine (VI) to intermediate (VII) would yield the formation of compound (IV) (Scheme 2). Alternatively...
International Journal of Peptide Research & TherapeuticsPinzon-Martin, S.M.; Medina, R.F.; Iregui Castro, C.A.; Rivera Monroy, Z.J.; Garcia Castaneda, J.E. Novel synthesis of N-glycosyl amino acids using T3P(R): Propylphosphonic acid cyclic anhydride as coupling reagent. Int. J. Pept....
In this paper is presented a novel and simple synthetic pathway for obtaining new protected and unprotected N-glucosyl amino acids from 2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosyl amine and Fmoc-l-amino acids. Three methodologies were evaluated, using the coupling reagents: N,N,N',N'-...