HAND2-AS1缺乏会损害移植后继发性肿瘤的改建能力(图2C和D),这种差异在连续移植中增加(图2E和F)。图2G为首次移植后不同组群抽搐的估计频率。将抗Hand 2-AS1的sgRNAs导入含荧光素酶载体的Huh 7细胞(Huh7-Luc)中 ,HAND2-AS1缺失显著降低了异种移植物的原位生长,显著抑制了生物发光(图H,I)。研究者还使用反...
HAND2-AS1 targeting miR-1208/SIRT1 axis alleviates foam cell formation in atherosclerosisLingyun MaShigui HeHelan LiShengli ZhangYi Yin
Moreover, HAND2-AS1 was involved in tumor cell proliferation, differentiation, apoptosis, and cellular glucose metabolism. This review summarizes data on the expression profile, functions, underlying mechanism, and clinical value of HAND2-AS1 in cancer. The expression profile of HAND2-AS1 in 33 ...
Moreover, flow cytometry analysis revealed that pHAND2-AS1 transfection promoted cell apoptosis (Figure 2D). Figure 2 LncRNA HAND2-AS1 overexpression inhibited PCa. Notes:(A) pHAND2-AS1 transfection increased HAND2-AS1 level in PCa cells. (B) CCK‐8 assay showed pHAND2-AS1 group...
et al. Retraction Note to: lncRNA HAND2-AS1 is downregulated in osteoarthritis and regulates IL-6 expression in chondrocytes. J Orthop Surg Res 17, 313 (2022). https://doi.org/10.1186/s13018-022-03206-1 Download citation Published14 June 2022 DOIhttps://doi.org/10.1186/s13018-022-...
lncRNA HAND2-AS1migrationmiRNA-21proliferationLong noncoding RNA (lncRNA) HAND2‐AS1 is a well‐characterized tumor suppressor in several types of malignancies, while its role in esophagus squamous cell carcinoma (ESCC) is unknown. In this study, we found that lncRNA HAND2‐AS1 was ...
HAND2-AS1 could be packaged into hMSC-derived exosomes and absorbed by RA-FLSs, and human MSC-derived exosomal HAND2-AS1 also repressed above malignant biological behavior of RA-FLSs. Conclusion MSC-derived exosomes participated in the intercellular transfer of HAND2-AS1 and suppressed the ...
Moreover, HAND2-AS1 has been shown to regulate expression of several targets with possible roles in the carcinogenesis through serving as a sponge for miRNAs. This lncRNA can also influence activity of BMP, TGF-尾1, JAK/STAT and PI3K/Akt pathways. Down-regulation of HAND2-AS1 in tumor ...
Objective To investigate the expression and clinical significance of long non-coding RNA (lncRNA) heart and neural crest derivatives express transcript 2 antisense sequence 1 (HAND2-AS1) in serum of patients with cervical cancer. Methods A total of 50 patients with...
HAND2-AS1 silencing on tumor formation ability.RESULTS We found that UTMBs carrying HAND2-AS1 restricted cell proliferation,invasion,and EMT,encouraged apoptosis,and HAND2-AS1 silencing eliminated the effect of UTMBs.Additionally,miR-873-5p targets the gene HAND2-AS1,which also targets the 3'UTR...