According to the invention, the halogenase can specifically synthesize 5'-FDA, and the catalytic activity thereof is equivalent to that of known halogenase FlA. When L-amino acid oxidase is added, the halogenase also can catalyze formation of 5'-ClDA.瞿旭东...
tryptophan halogenaseHalogenases are valuable biocatalysts for selective C–H activation, but despite recent efforts to broaden their application scope by means of protein engineering, improvement of thermostability and catalytic efficiency is still desired. A directed evolution campaign aimed at generating...
Tryptophan 7-Halogenase (PrnA) Structure Suggests a Mechanism for Regioselective Chlorination Unversucht, S, Haupt, C, Pee, KH, Naismith, JH (2005) Tryptophan 7-halogenase (PrnA) structure suggests a mechanism for regioselective chlorination. Sc... C.,Dong - 《Science》 被引量: 0发表: 2005...
Copper-dependent halogenase catalyses unactivated C−H bond functionalization Chen-Yu Chiang Masao Ohashi Yi Tang Nature(2025) Biocatalytic enantioselective C(sp3)–H fluorination enabled by directed evolution of non-haem iron enzymes Liu-Peng Zhao ...
tryptophan halogenaseswhole-cell reactionsChanging nature : Tryptophan halogenases, which play an important role in the biosynthesis of halogenated indole alkaloids, are found in diverse organisms and catalyze regiospecific halogenation. A tryptophan 6‐halogenase from S.albus is identified, and key ...
halogenase (VirX1) from a cyanophage. Notably, halogenases have been previously associated with secondary metabolism, tailoring natural products. Exploration of this viral halogenase reveals it capable of regioselective halogenation of a diverse range of substrates with a preference for forming aryl ...
Analysis of the halogenase gene in actinomycetes from different habitats and its implications for halometabolite discovery ?不同生境放线菌的卤化酶基因分析及其对卤代产物筛选的意义Analysis of the halogenase gene in actinomycetes from different habitats and its implications for halometabolite discovery ?不...
Halometabolites, an important group of natural products, generally require halogenases for their biosynthesis. Actinomycetes from the Arctic Ocean have rarely been investigated for halogenases and their gene clusters associated, albeit great potential of halometabolite production has been predicted. Therefo...
当当中华商务进口图书旗舰店在线销售正版《海外直订Engineering of Halogenases Towards Synthetic Applications: Increasing 卤代酶的合成应用工程:提高热稳定性和海洋溴化酶Bm》。最新《海外直订Engineering of Halogenases Towards Synthetic Applications: Increasing
The distribution of these peptide synthetase gene clusters, among the tested Microcystis strains, was found in relative agreement with their phylogeny reconstructed from 16S-23S rDNA intergenic spacer sequences, whereas the distribution of the associated halogenase genes appears to be sporadic. The ...