Halogenating enzymes are able to introduce halogen substituents under ambient conditions using non﹉azardous reagents with intriguing selectivity, which is highly desired in green chemistry. Although C–H functionalization such as halogenation is a well﹌nown transformation in synthetic chemistry, the ...
Halocyclization of alkenes is a powerful bond-forming tool in synthetic organic chemistry and a key step in natural product biosynthesis, but catalyzing halocyclization with high enantioselectivity remains a challenging task. Identifying suitable enzymes
Development of halogenase enzymes for use in synthesis. Chem. Rev. 118, 232–269 (2018). Article CAS PubMed Google Scholar Andorfer, M. C. & Lewis, J. C. Understanding and improving the activity of flavin-dependent halogenases via random and targeted mutagenesis. Annu. Rev. Biochem. ...
Extending the biocatalytic scope of regiocomplementary flavin-dependent halogenase enzymes (33) Yeh, E., Garneau, S., and Walsh, C. T. (2005) Robust in vitro Activity of RebF and RebH, a Two-Component Reductase/Halogenase, Generating 7-chlorotryptophan during rebeccamycin biosynthesis. Proc....
Initial enzyme engineering examples indicate that the accessible substrate range of these enzymes may be expanded whereas their throughout biophysical characterization continues to inform about the principles governing the halogenation mechanism. For more information see the Concept article by R. Buller et ...
公司名称:Creative Enzymes推荐 联系电话:1-516-855-7709 电子邮件:info@creative-enzymes.com 国籍:美国 产品介绍:英文名称:tryptophan 7-halogenase 备注:In the bacterium Lechevalieria aerocolonigenes the enzyme catalyses the initial step in the biosynthesis of rebeccamycin. Also acts on bromide ion. ...
全球有 2家供应商TRYPTOPHAN 7-HALOGENASE国内生产厂家 供应商联系电话电子邮件国家产品数优势度 Creative Enzymes1-516-855-7709info@creative-enzymes.com美国874858 198575-11-0, TRYPTOPHAN 7-HALOGENASE相关搜索: 色氨酸合成酶 198575-11-0 tryptophan 7-halogenase...
The first motif (GxGxxG) is located near the N terminus of the protein and is known to be involved in the binding of nucleotide cofactors and is common to a number of FAD- and NAD(P)H-dependent enzymes [12]. The second motif (GWxWxIP), also conserved in all known FADH2-dependent ...
FeII/α-ketoglutarate (FeII/αKG)-dependent enzymes offer a promising biocatalytic platform for halogenation chemistry owing to their ability to functionalize unactivated C–H bonds. However, relatively few radical halogenases have been identified to date, limiting their synthetic utility. Here, we ...
H. Catalytic mechanisms, basic roles, and biotechnological and environmental significance of halogenating enzymes. Acta Biochim. Biophys. Sin. (Shanghai) 40, 183–193 (2008). 31. Drienovska, I., Chovancova, E., Koudelakova, T., Damborsky, J. & Chaloupkova, R. Biochemical characterization...