Minhong Huang的实验表明[6]:继发性锰损伤后,LPS引发的小胶质细胞中关键促炎标志物水平升高。此外, LPS 引发的小胶质细胞 H3K27ac 和 H3K4me3以及 H3K4me1的沉积增强。进一步的p300/H3K27ac抑制剂GNE-049共处理降低了p300表达和H3K27ac沉积,减少iNOS,增加M2极化标记ARG1和IRF4水平。同时,GNE-049可减少线粒体...
Minhong Huang的实验表明[6]:继发性锰损伤后,LPS引发的小胶质细胞中关键促炎标志物水平升高。此外, LPS 引发的小胶质细胞 H3K27ac 和 H3K4me3以及 H3K4me1的沉积增强。进一步的p300/H3K27ac抑制剂GNE-049共处理降低了p300表达和H3K27ac沉积,减少iNOS,增加M2极化标记ARG1和IRF4水平。同时,GNE-049可减少线粒体...
Minhong Huang的实验表明[6]:继发性锰损伤后,LPS引发的小胶质细胞中关键促炎标志物水平升高。此外, LPS 引发的小胶质细胞 H3K27ac 和 H3K4me3以及 H3K4me1的沉积增强。进一步的p300/H3K27ac抑制剂GNE-049共处理降低了p300表达和H3K27ac沉积,减少iNOS,增加M2极化标记ARG1和IRF4水平。同时,GNE-049可减少线粒体...
Display of H3K4me3 and H3K27ac tracks for both NCCIT and TCam-2. (A) SOX17, (B) SOX2, (C) OCT3/4 (POU5F1), (D) NANOG.Yvonne, G. van der Zwan
在 H3K27ac+ 区域,启动子中的 H3K9ac:H3K27ac 比率高于远端区域;H3K4me3:H3K27ac 比率在活性启动子中甚至高于远端区域(图 2e)。值得注意的是,H2BNTac:H3K27ac 比率显示出相反的模式;H2BNTac:H3K27ac 比率在远端区域比活性启动子高得多。H3K9ac+ 和 H2BK20ac+ 区域的分析进一步证实了这些差异。
研究表明,H3K4me1和H3K4me3与基因激活相关,H3K4me3主要富集在转录起始位点附近的启动子区域,而大多数H3K4me1修饰富集在增强子区域;H3K27ac与基因激活相关,主要富集在增强子和启动子区域,当增强子区只有H3K4me1修饰富集时,该增强子处于平衡状态,而当增强子区域同时富集H3K4me1和H3K27ac修饰时,该增强子就处于激活状态促进...
Clinical Epigenetics (2022) 14:112 https://doi.org/10.1186/s13148-022-01331-6 RESEARCH Open Access Serum level of total histone 3, H3K4me3, and H3K27ac after non‑emergent cardiac surgery suggests the persistence of smoldering inflammation at 3 months in an adult ...
Background: Long noncoding RNAs (lncRNAs) are abnormally expressed in a broad type of cancers and play significant roles that regulate tumor development and metastasis. However, the pathological roles of lncRNAs in esophageal squamous cell carcinoma (ESCC) remain largely unknown. Here we aimed to ...
Transcriptionally active chromatin is marked by tri-methylation of histone H3 at lysine 4 (H3K4me3) located after first exons and around transcription start sites. This epigenetic mark is typically restricted to narrow regions at the 5`end of the gene body, though a small subset of genes have ...
2, Gino Nardocci3,4, Igor Kovalchuk5, Andre J. van Wijnen6,7 and James R. Davie1,2* Abstract Transcriptionally active chromatin is marked by tri-methylation of histone H3 at lysine 4 (H3K4me3) located after first exons and around transcription start sites. ...