每个通道代表在参考人群中鉴定的具有DNA低甲基化(23,023)、中甲基化(8,087)、高甲基化(16,777)或未知甲基化(没有CpG或在WGBS中覆盖小于10倍的CpG)的H3K4me3 peaks区域,或者未被H3K4me3标记的H3K27me3精子peaks区域。 (5)精子中的H3K4me3靶向增强子和逃避表观遗传重编程区域 图7:H3K4me3在hESC增强子和逃避重...
图6:H3K4me3精子peaks区域的H3K4me3/H3K27me3二价性,存在低、中或高DNA甲基化 H3K4me3和H3K27me3信号(单位:RPKM)在H3K4me3 peaks中心(±5kb)在人类精子(参考30名男性的H3K4me3和已发表的H3K27me3数据(hamoud etal ., 2009))、8细胞人类胚胎和内细胞团(Xia etal .,2019)、 hESC (Grandy etal ., 2015)...
图6:H3K4me3精子peaks区域的H3K4me3/H3K27me3二价性,存在低、中或高DNA甲基化 H3K4me3和H3K27me3信号(单位:RPKM)在H3K4me3 peaks中心(±5kb)在人类精子(参考30名男性的H3K4me3和已发表的H3K27me3数据(hamoud etal ., 2009))、8细胞人类胚胎和内细胞团(Xia etal .,2019)、 hESC (Grandy etal ., 2015)...
图6:H3K4me3精子peaks区域的H3K4me3/H3K27me3二价性,存在低、中或高DNA甲基化 H3K4me3和H3K27me3信号(单位:RPKM)在H3K4me3 peaks中心(±5kb)在人类精子(参考30名男性的H3K4me3和已发表的H3K27me3数据(hamoud etal ., 2009))、8细胞人类胚胎和内细胞团(Xia etal .,2019)、 hESC (Grandy etal ., 2015)...
acids of H3.3 is identical to the other H3s, except at amino acid position 31.BThe broad epigenetic domain of theGATA3gene in MCF7 breast cancer cells. ChIP-Seq (H3K4me3, H3K27ac, CHD1) and DNase-seq tracks at theGATA3gene are shown [80]. Me2s, symmetric dimethylation, Ac, ...
b, The percentage of overlapping H3K4me3 peaks between the top-10,000 H3K4me3 peaks detected from multiple μChIP–seq experiments with different numbers of human NCCIT cells. c, A genome browser snapshot for H3K27ac and H3K4me3 μChIP–seq in mouse E14 ES cells. ENCODE ChIP–seq is also ...
KDM KAT PRMT SET Broad epigenetic domain H3.3 [CH] CHD1 [CH] H3 B. Drug sensitivity Broad epigenetic domain Doxorubicin Histone octamer NFR DetecƟon of nucleosome-free region (NFR) DNase-Seq FAIRE-Seq FAIRE H3K4me3 H3K27ac H3R2me2s H4R3me2a Fig. 4 Model for nucleosome ...
GC content. In addition to being poorly methylated, tiles where TKO specifically loses H3K27me3 were more GC rich (Fig.1c). In contrast, besides association with high 5meC levels, TKO-specific H3K27me3 ‘gain’ tiles were of lower GC content (Fig.1c) [35]. For example, we show ...
(b) Relative PLOD2 messenger RNA (mRNA) expression, after co-transfection of dCas9 fusions and a combination of gRNAs. (c) H3K4me3 and H3K79me3 ChIP–qPCR enrichment at the promoter region of PLOD2 (around TSS and 750 bp upstream. (d) Relative EpCAM mRNA, after co-transfection in ...
Genome-wide profiling of histone (H3) lysine 4 (K4) tri-methylation (me3) under drought, heat, and combined stresses in switchgrass. BMC Genomics. 2024;25(1):223. Article CAS PubMed PubMed Central Google Scholar Chen K, Chen Z, Wu D, Zhang L, Lin X, Su J, Rodriguez B, Xi Y...