H3K9me3 and H3K27me3 in an adult germinal niche THE UNIVERSITY OF TEXAS AT SAN ANTONIO Chin-Hsing Annie Lin RhodesChristopherNeural stem cells (NSCs) participate in a delicate balance between maintaining cellular identity through self-renewal and differentiating into myriad neural cell types. ...
确实,敲低MLL2后,MLL2靶基因的5mC和H3K27me3显著升高,这与敲低MLL2后这些基因表达降低的现象相符,也说明MLL2缺失导致的基因表达抑制是由DNA甲基化和H3K27me3介导的。而SET1A/B的敲低显著降低DNMT1的表达,使得MLL2靶基因处的...
1 SHL binds H3K27me3 and H3K4me3. a The domain architecture of Arabidopsis SHL (AtSHL). BAH, bromo-adjacent homology; PHD, plant homeodomain. b Systematic profiling of histone binding preferences of full- length AtSHL on a histone peptide microarray. Representative array images showing that ...
(CMT3) contains a BAH domain and a chromodomain, both interacting with the repressive mark H3K9me229. Interestingly, the PHD-bromo cassette of TRIM33 can recognize both the silencing mark H3K9me3 and the active mark H3K18ac30. In plants, the histone mark readers are generally similar to ...
除上述修饰外,本研究还发现了H3K36me3与H3K27ac也富集于重组热点,而H3K9me2修饰则缺失于重组热点;同时,观察到重组热点区域的染色质与全基因组相比更加开放。有意思的是,不论H3K36me3与H3K27ac的富集,还是H3K9me2的缺失,抑或染色质的开放,均随Prdm9敲除而变化,表明上述表观因子均为PRDM9依赖性的。与H3K4me3...
G9a-GLP异二聚体促进H3K9me1和H3K9me2沉积并抑制靶基因表达。G9a-GLP可以通过与多种DNA结合蛋白的直接相互作用来招募靶向基因启动子。 3、H3K27 H3K27me3是转录抑制的标志。PRC2复合物中的EZH2亚基是一种H3K27甲基转移酶,负责催化H3K27的三种甲基化状态。PRC2复合物由四个核心亚基组成:EZH1/2、SUZ12、...
Dynamic epigenetic regulation of the Oct4 and Nanog regulatory regions during neural differentiation in rhesus nuclear transfer embryonic stem cells. 27 trimethylation (H3K4me3, H3K9me3, and H3K27me3) showed similar patterns around the regulatory regions of Oct4 and Nanog in both kinds of ES cells...
目的观察饮水砷暴露对人群外周血白细胞中组蛋白H3第4位赖氨酸三甲基化(H3K4me3)和H3第79位赖氨酸三甲基化(H3K79me3)修饰水平的影响,分析砷暴露与H3K4me3和H3K79me3修饰水平的关系。 方法采用整群抽样的调查方法,在山西省和吉林省饮水型地方性砷中毒典型病区开展现场调查,选择饮水年限≥10年的当地常住居民281人...
www.nature.com/scientificreports OPEN received: 01 April 2015 accepted: 22 July 2015 Published: 19 August 2015 Histone H3K4me3 and H3K27me3 regulatory genes control stable transmission of an epimutation in rice Xiangsong Chen1, Xiaoyun Liu1,2, Yu Zhao1 & Dao-Xiu Zhou1,3 DNA ...
For example, trimethylation of H3K4 and H3K79 and monomethylation of H3K27, H3K9, and H4K20 are associated with gene activation, whereas di- and trimethylation of H3K27 are associated with gene repression. Although H3K4me3 and H3K27me3 are usually enriched at active and inactive chromatin ...