一 tinib had neither additive nor synergistic effect.Conclusion TQ combined with Gef itinib treatment dose not increase the cytotoxicity ofEGFR—L858R/T790M mutant H1975 cell line. 【Key words】 Thymoquinone;Gef itinib;Epider m al growth factor receptor;Mutation;Combined therapy 肺癌是男性发病率...
(P < 0.05).There were no difference in EGFR gene mutation between NCI-H1975 and its subpopulations.Conclusions NCI-H1975 were heterogeneous on proliferation ability and drug reactivity and its heterogeneity were associated with sensitivity and resistance of drug treatment.%目的 探讨人非小细胞肺癌NCI...
摘要 [目的]分析人肺腺癌吉非替尼耐药细胞株H1975(epidermal growth factor receptor,EGFR基因双突变)和人肺腺癌吉非替尼敏感细胞株PC9(EGFR单突变)细胞株微小RNA(microRN...展开更多 [Purpose] To differentiate microRNA(miRNAs) profiles in EGFR double mutations cell line-H1975 versus EGFR single mutation ...
acquired resistance universally develops in many patients responding to these drugs (9,10). In the past several years, studies have revealed the two molecular mechanisms for acquired resistance: a secondary T790M mutation in EGFR and Met amplification (11–13). To overcome the acquired resistance ...
(P < 0.05).There were no difference in EGFR gene mutation between NCI-H1975 and its subpopulations.Conclusions NCI-H1975 were heterogeneous on proliferation ability and drug reactivity and its heterogeneity were associated with sensitivity and resistance of drug treatment.%目的 探讨人非小细胞肺癌NCI...
phosphorylation of several proteins of the PI3K/AKT signaling pathway and the mRNA expression levels of HIF1-α, VEGF and MMP9 in the acquired gefitinib resistant cell line H1975 were investigated, and whether NVP-BKM120 can overcome the acquired resistance caused by the EGFR T790M mutation and...
MelatoninH1975HCC827EGFRBcl-2AKTBad Our findings demonstrate that melatonin acts as a potent chemotherapeutic agent by sensitising to gefitinib TKI-resistant H1975 cells that harbour a EGFR T790M mutation.doi:info:doi/10.1159/000366305Miyong YunEun-Ok KimDuckgue LeeJi-Hyun KimJaekwang KimHyemin ...
The clinical efficacy of gefitinib in the treatment of non-small cell lung cancer (NSCLC) with mutations in exon 18, 19 or 21 of epidermal growth factor receptor (EGFR) is limited by the acquired resistance to the drug. To explore whether X-ray irradiation could reverse the acquired ...
Furthermore, matrine treatment was demonstrated to increase the inhibitory effects of afatinib on H1975 cells with the T790M EGFR mutation.Shui-FangChenZe-YingZhangJian-LiingentaconnectMolecular Medicine ReportsMatrine increases the inhibitory effects of afatinib on H1975 cells via the IL 6/JAK1/...
and whether NVP-BKM120 can overcome the acquired resistance caused by the EGFR T790M mutation and the underlying mechanism were explored.MTT assay was performed to detect the effect of gefitinib,NVP-BKM120,NVP-BKM120 plus 1μmol/L gefitinib on growth of H1975 cells.The distribution of cell ...