"Impact of EGFR Exon 19 Deletion Subtypes on Clinical Outcomes in EGFR-TKI-Treated Advanced Non-Small-Cell Lung Cancer." Lung Cancer (2022). [2]Grant MJ, Aredo JV, Starrett JH, Stockhammer P, et,al. Efficacy of Osimertinib in Patients with Lung Cancer Positive for Uncommon EGFR Exon 19...
15. Gao W, et al. Association Of Initial Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors Treatment And EGFR Exon 19 Deletion With Frequency Of The T790M Mutation In Non-Small Cell Lung Cancer Patients After ...
[1]Huang, Le-Tian, et al. "Impact of EGFR Exon 19 Deletion Subtypes on Clinical Outcomes in EGFR-TKI-Treated Advanced Non-Small-Cell Lung Cancer." Lung Cancer (2022). [2]Grant MJ, Aredo JV, Starrett JH, St...
[1]Huang, Le-Tian, et al. "Impact of EGFR Exon 19 Deletion Subtypes on Clinical Outcomes in EGFR-TKI-Treated Advanced Non-Small-Cell Lung Cancer." Lung Cancer (2022). [2]Grant MJ, Aredo JV, Starrett JH, Stockhammer P, van Alderwerelt van Rosenburgh IK, Wurtz A, Piper-Valillo AJ...
[4].Chan S K, Choi H C W, Lee V H F. Overall survival benefits of first-line treatments for Asian patients with advanced epidermal growth factor receptor-mutated NSCLC harboring exon 19 deletion: a systematic review and network meta-analysis[J]. Cancers, 2022, 14(14): 3362. ...
growth factor receptor, EGFR）是一种细胞表面酪氨酸激酶受体，EGFR激酶结构域18-21外显子突变是非小细胞肺癌（non-small cell lung cancer, NSCLC）确定的驱动突变基因，EGFR最常见的典型突变是19外显子缺失突变（exon 19 deletion, Ex19del）和21外显子氨基酸替换L858R的错义突变（exon 21 point mutation, ...
3. Y.W. Choi, S.Y. Jeon, G.S. Jeong, et al., EGFR exon 19 deletion is associated with favorable overall survival after frst-line gefitinib therapy in advanced non-small cell lung cancer patients, Am. J. Clin. Oncol. 41 (2018) 385–390 ...
EGFR突变阳性肺癌的特点有非吸烟、女性、GGO、无淋巴管脉管浸润。经多变量分析后发现EGFR阳性肺癌的预后略好于阴性肺癌,阳性对比阴性的无进展生存时间(PFS)HR比为0.894,p=0.017。EGFR阳性肺癌的主要变异点位为exon19 deletion(Del 19)和 L858R point mutation(L858R)。研究对象中两个点位的受试者数:Del 19(983例)...
Osimertinib-induced BRAF mutation in a single metastatic lesion among multiple pulmonary lesions in a case of lung cancer with EGFR exon 19 deletion.Hiroyuki Miura, Jun Miura, Shinichi Goto, Tomoko Yamamoto.https://doi.org/10.1002/rcr2.70003...
While the MB hybridizes to both the wild and mutant target DNA, the oligo-Q only binds to the wild target DNA, leading to a fluorescent signal in case of deletion mutation. This enables the comprehensive detection of the diverse exon 19 deletion mutations using a single probe set. We ...