Macrophages are among the important members of the immune system, which perform dual roles in GVHD as both therapeutic tools and targets. This review epitomizes the multifunctional role of macrophages in the pathophysiology of both acute and chronic GVHD. Macrophages play an important role in the ...
Symptoms of gut graft-versus-host disease (GVHD) are frequent watery diarrhea accompanied by intolerable pain, bloody stool, and paralytic ileus, and these symptoms have serious detrimental effects on both the physical and mental health of patients. It is very difficult to treat severe gut GVHD a...
Reports on the use of lactoferrin for gut graft-versus-host disease (GVHD). Symptoms of GVHD; Functions of lactoferrin.doi:10.1038/SJ.BMT.1703283M. InoueT. OkamuraM. YasuiN. SakataK. YagiK. KawaBone Marrow TransplantationInoue M, Okamura T, Yasui M, Sakata N, Yagi K, Kawa K (2001) ...
reported on the successful treatment of severe steroid-resistant grade IV GvHD of the gut and the liver after unrelated allogeneic SCT in a 9-year-old boy with haploidentical third-party bone marrow-derived MSCs [64]. This observation was supported by a multicenter non-randomized phase II study...
Studies using murine models of allogeneic bone marrow transplantation have established that α4β7 integrin receptor-mediated trafficking of T cells to gut lymphoid tissue has an important role in the gut invasion of alloreactive donor T cells, leading to the development of aGVHD20,21. Further ...
Therefore, it is important to identify novel therapeutic strategies to maintain the efficacy of GVL [3]. There have been recently reported that the addition of novel agents focused on immunomodulatory such as cytotoxic T-cell-lymphocyte-4-immunoglobulin, dipeptidyl peptidase 4 inhibitor, and gut-...
In addition to simply confirming that the symptoms presenting are in fact the result of GVHD, the lines between the 2 types—acute and chronic—can be blurry. “It used to be very easy, because 100 days was the break point,” said Chao. “Anything before 100 days was labeled ‘acute,...
Nelson J. Chao, MD, MBA, and Yi-Bin Chen, MD, define common signs and symptoms of GVHD and share insight on approaching the diagnosis of disease.Now Viewing EP: 1.Overview of Graft-vs-Host Disease (GVHD) EP: 2.Challenges in Early Detection of GvHD EP: 3.Selecting GVHD Prophylaxis EP...
Furthermore, aGvHD severity strongly associates with the clonal expansion of mainly CD8 T cells, which we find distributed over anatomically distant regions of the gut, persistent over time, and inversely correlated with the presence of suppressive Tregs. Overall, our study highlights the ...
Studies using murine models of allogeneic bone marrow transplantation have established that α4β7 integrin receptor-mediated trafficking of T cells to gut lymphoid tissue has an important role in the gut invasion of alloreactive donor T cells, leading to the development of aGVHD20,21. Further ...