Reduced incidence of acute graft versus host disease (GVHD) of the gut in Chinese carriers of Helicobacter pylori during allogeneic bone marrow transplantation. Ann Hematol 2004; 83: 34-37.Au WY, Wong RW, Wong BC, et al. Reduced incidence of acute graft-versus-host disease (GVHD) of the ...
CSA and TAC inhibit GVHD by preventing the activation of the nuclear factor of activated T-cell (NFAT) family of transcription factors, thereby reducing the transcription of interleukin-2 and the activation of effector T-cells, albeit with a concurrent reduction in levels of interleukin-2-dependent...
acute GVHD are involved in the pathophysiology of the disease. First, the process of conditioning results in injury to the tissue, thus causing the activation of antigen-presenting cells (APCs), which proceed to preset the antigens specific to the recipient. The subsequent stage, known as the ...
In the acute setting, which is what happens early on, a strong cytokine-driven process by the T cells causes disease in the skin, gut, and liver. In the chronic sense, it’s much more of an autoimmune-type process. T cells are critical to start it, but afterward, there are many ...
reported on the successful treatment of severe steroid-resistant grade IV GvHD of the gut and the liver after unrelated allogeneic SCT in a 9-year-old boy with haploidentical third-party bone marrow-derived MSCs [64]. This observation was supported by a multicenter non-randomized phase II study...
If the gut works, enteral nutrition is the preferred route of feeding during recovery from allogeneic hematopoietic stem cell transplantation. Yet, patients with gastrointestinal GvHD (GI-GvHD) with intolerance for enteral nutrition and progressive weight loss often require parenteral nutrition. GI-GvHD ...
All of them received bone-marrow grafts from HLA matched, MLC nonreactive, sibling donors, were nursed in laminar down-flow isolators with selective gut decontamination, and received GvHD prophylaxis with methotrexate. The number of nucleated cells in the marrow graft/kg body weight of the ...
We think that there is a very important and very poorly understood interaction between our own innate immune system and the common cell organisms that live in our gut. We’re learning now how some of these organisms might actually be proinflammatory, [and] how dysbiosis or a change in our ...
We report a single-center phase I/II trial exploring the combination of everolimus (EVE) and mycophenolate mofetil (MMF) as calcineurin inhibitor (CNI)-fre
We assume that the damaged gut mucosal barrier in GVHD enables the microbubbles to penetrate through the bowel wall into the bowel lumen. The penetration of microbubbles into the bowel lumen may serve as a novel diagnostic feature for GVHD if confirmed in controlled clinical trials. This is a ...