microbiotaIMMUNESystemLiverdiseaseMetabolSeveral studies revealed that gut microbiota are associated with various human diseases,e.g.,metabolic diseases,allergies,gastroenterological diseases,and liver diseases.The liver can be greatly affected by changes in gut microbiota due to the entry of gut bacteria ...
The gut microbiota is a complex and plastic consortium of microorganisms that are intricately connected with human physiology. The liver is a central immunological organ that is particularly enriched in innate immune cells and constantly exposed to circu
Gut Microbiota and Liver Diseases The gut microbiota plays a crucial role in the maintenance of human health. It is a complex ecosystem of microorganisms that resides in the gastrointestinal tract and helps in the digestion and absorption of nutrients. However, recent studies have shown that ...
liver through the portal vein,and the liver-gut axis is important to understand the pathophysiology of several liver diseases,especially non-alcoholic fatty liver disease and hepatic encephalopathy.Moreover,gut microbiota play a significant role in the development of alcoholic liver disease and ...
2.1. Gut microbiota and NAFLD as well as NASH NAFLD is a global public health problem because of the prevalence of obesity.13 NAFLD is a spectrum of chronic liver diseases, including simple steatosis, NASH, advanced fibrosis, cirrhosis, and HCC.6 Dysbiosis refers to unfavorable alteration of th...
Alcoholic liver disease, which ranges from mild disease to alcoholic hepatitis and cirrhosis, is a leading cause of morbidity and mortality worldwide. Alcohol intake can lead to changes in gut microbiota composition, even before liver disease development. These alterations worsen with advancing disease...
Fabbrini, E., Sullivan, S. & Klein, S. Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications.Hepatology51, 679–689 (2010). CASPubMedGoogle Scholar Bäckhed, F.et al. The gut microbiota as an environmental factor that regulates fat storage.Proc. Na...
gut microbiota; inflammasome; innate immunity; probiotic; tolerance; Toll-like receptor The liver constantly encounters food-derived antigens and bacterial components such as lipopolysaccharide translocated from the gut into the portal vein. Bacterial components stimulate Toll-like receptors (TLR), which ...
Reducing the number of intestinal bacteria with antibiotic treatment is generally advantageous in experimental liver diseases. Complete absence of intestinal microbiota as in germ-free rodents can be protective in autoimmune hepatitis and hepatic tumors induced by chemicals, or it can exacerbate disease ...