Alcoholic liver disease, which ranges from mild disease to alcoholic hepatitis and cirrhosis, is a leading cause of morbidity and mortality worldwide. Alcohol intake can lead to changes in gut microbiota composition, even before liver disease development
Chronic heavy alcohol use can modulate the composition and function of the gut microbiota, thereby exacerbating end‐organ damage via the gut–brain axis and the gut–liver axis. In this review, we summarize the bacterial, fungal, and viral gut microbial compositional changes associated with ...
Microbiota changes might also alter brain function, and the gut–brain axis might be a potential target to reduce alcoholic relapse risk. Gut microbiota manipulation including probiotics, faecal microbial transplant and antibiotics has been studied in alcoholic liver disease with varying success. Further...
Alcohol, liver disease and the gut microbiota. Nat. Rev. Gastroenterol. Hepatol. 16, 235–246 (2019). Article Google Scholar Dubinkina, V. B. et al. Links of gut microbiota composition with alcohol dependence syndrome and alcoholic liver disease. Microbiome 5, 141 (2017). Article Google ...
Alcohol, liver disease and the gut microbiota. Nat. Rev. Gastroenterol. Hepatol. 16, 235–246 (2019). Article Google Scholar Dubinkina, V. B. et al. Links of gut microbiota composition with alcohol dependence syndrome and alcoholic liver disease. Microbiome 5, 141 (2017). Article Google ...
Recent advances in microbiome and alcohol research have shown that AUD negatively affects not only the liver and other organ systems but also the gastrointestinal system and its indigenous microbiota. Individuals with AUD exhibit alterations in their gut microbiome, characterized by reduced levels of bac...
and even liver cancer.87Excessive alcohol consumption can affect the composition and abundance of the intestinalmicrobiotaand is associated with increased transfer of microbial products from the gut to the liver via theportal circulation.88Previously, Riva et al89reported that peripheral blood MAIT cell...
Bajaj, J. S. Alcohol, liver disease and the gut microbiota.Nat. Rev. Gastroenterol. Hepatol.16, 235–246 (2019). ArticlePubMedGoogle Scholar Duan, Y.et al.Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease.Nature575, 505–511 (2019). ...
The importance of gut microbiota in alcohol-related liver disease and liver cancer has been demonstrated in two studies presented at the Digital International Liver Congress 2020. The key role of microbial biodiversity in the gut was highlighted in a study of fecal microbial transplantation. The tech...
Gut microbiota has been implicated in the pathogenesis of alcohol-related liver diseases, with its composition manifesting expressed dysbiosis in patients suffering from alcoholic dependence. Due to its inherent plasticity, gut microbiota is an important target for prevention and treatment of these ...