具体来说RhoA,Cdc42和Rac1可以通过诱导肌动蛋白单体的聚合以及肌动蛋白丝的稳定来调控纤毛的发育和维持,以及作为细胞极性调控的重要元件来影响听觉毛细胞纤毛束的正常形态的定向,同时他们介导的肌动蛋白相关通路在外毛细胞
参考文献: [1]. Agola JO, et al. A competitive nucleotide binding inhibitor: in vitro characterization of Rab7 GTPase inhibition. ACS Chem Biol. 2012 Jun 15;7(6):1095-108. [2]. Lam T, et al. Small Molecule Inhibition of Rab7 Impairs B Cell Class Switching and Plasma Cell Survival To ...
The Rho family of small GTP-binding proteins comprises a group of signaling molecules that are activated by a variety of Growth factors, Cytokines, Adhesion molecules, Hormones, Integrins, G-proteins and other biologically active substances and regulate a wide range of biological processes, including...
Small GTP-binding proteins. Physiol Rev, 2001, 81(1): 153-208. Deneka M, Neeft M, van der Sluijs P. Regulation of membrane transport by Rab GTPases. Crit Rev Biochem Mol Biol, 2003, 38(3): 121-142. Soldati T, Riederer MA, Pfeffer SR. Rab GDI: a solubilizing and recycling ...
(Ranbindingprotein1)是一种分子量为23kDa的蛋白 质,本身没有GAP活性,但它可以作为GEF抑制 剂降低RCC1的活性,从而间接提高GDP和GTP的 比值【8(图1B). Ran在真核细胞的一系列生物过程中,如DNA 复制,RNA的转录和加工,RNA和蛋白质从核孔 复合物的转运,有丝分裂和减数分裂的控制,尤其 ...
中国寄生虫学与寄生虫病杂志2010年6月第28卷第3期ChinJParasitolParasitDisJune2010袁Vol.28袁No.3基金项目院国家高科技研究发展计划渊863计划冤渊No.2006AA02I..
11. Lin T, Zeng L, Liu Y, et al. Rho-ROCK-LIMK-cofilin pathway regulates shear stress activation of sterol regulatory element binding proteins. Circ Res. 2003;92(12):1296-1304. 12. Feng D, Wang J, Yang W, et al. Regulation of Wnt/PCP signaling through p97/VCP-KBTBD7-mediated Va...
11. Lin T, Zeng L, Liu Y, et al. Rho-ROCK-LIMK-cofilin pathway regulates shear stress activation of sterol regulatory element binding proteins. Circ Res. 2003;92(12):1296-1304. 12. Feng D, Wang J, Yang W, et al. Regulation of Wnt/PCP signaling through p97/VCP-KBTBD7-mediated Va...
11. Lin T, Zeng L, Liu Y, et al. Rho-ROCK-LIMK-cofilin pathway regulates shear stress activation of sterol regulatory element binding proteins. Circ Res. 2003;92(12):1296-1304. 12. Feng D, Wang J, Yang W, et al. Regulation of Wnt/PCP signaling through p97/VCP-KBTBD7-mediated Va...