This review describes, briefly, the characteristics and regulation of glycogen synthase kinase 3 (GSK3) together with the role of GSK3 dysfunctions in different pathologies, and GSK3 as target for therapeutic treatment in different diseases. Several GSK3 inhibitors acting at different levels are ...
The Wnt-signaling pathway, which includes GSK-3, is important in bone metabolism. The small molecule drug AZ2858 inhibits GSK-3. Oral administration of AZD2858 increases bone mineral density and content in rats. This increase enhances both vertebral compression and diaphyseal bending strength. AZD...
Arabidopsis glycogen synthase kinase 3 (GSK3)-like kinases have versatile functions in plant development and in responding to abiotic stresses. Although physiological evidence suggested a potential role of GSK3-like kinases in abscisic acid (ABA) signaling, the underlying molecular mechanism was largely...
Insulinomas (pancreatic islet β cell tumors) are the most common type of functioning pancreatic neuroendocrine tumors that occur sporadically or as a part of the MEN1 syndrome that is caused by germ line mutations inMEN1. Tissue-specific tumor predisposition from germ line mutations in ubiquitously...
BACKGROUND: Glycogen synthase kinase 3beta (GSK3B, GSK-3beta) is a multi-functional protein kinase involved in various cellular processes and its activity elevates after serum deprivation. We have shown that inhibition of GSK-3beta activity triggered a profound autophagic response and subsequent nec...
The properties of the differentiated cells in the two groups were analyzed on day 5, day 10, and day 20 during the process of hepatic differentiation of hASCs. Immunofluorescence staining data verified that, on day 5, the cells in the two groups were positive for GATA-binding protein 4 (...
The GSK-3 was first characterized for its role in glycogen metabolism by phosphorylating and inactivating the enzyme glycogen synthase. There are two mammalian GSK-3 isoforms encoded by distinct genes: GSK-3α and GSK-3β. GSK-3β is involved in the regulation of a wide range of cellular ...
Alcohol consumption during pregnancy is a significant public health problem and may result in a wide range of adverse outcomes for the child. The developing central nervous system (CNS) is particularly susceptible to ethanol toxicity. Children with fetal alcohol spectrum disorders (FASD) have a varie...
GSK3-IN-1,MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。GSK3-IN-1CAS No. : 478482-74-5MCE 国际站:GSK3-IN-1产品活性:GSK3-IN-1 (compound 11) 是一种 GSK-3 抑制剂, IC50 值为 12 μM。
This study investigated the role of GSK-3β in attenuation of cardioprotective effect of IPC in diabetic rat. DM was induced by single administration of streptozotocin (STZ, 50mg/kg, i.p.). Isolated perfused heart was subjected to 30min of ischemia followed by 120min of reperfusion. ...