Alzheimer's disease(AD)and diabetes m ellitus(DM)are two of the most common conditions that affect a large number of elderly people.Recent evidence from a population-based study shows a link between DM and AD,with an increase of AD as much as 2 to 5 times higher in population suffer ...
体内研究Oral administration of CHIR-99021 at 30mg/kg enhances glucose metabolism in a rodent model of type 2 diabetes, with a maximal plasma glucose reduction of nearly 150mg/dl 3-4 hours after administration, while plasma insulin remains at or below control levels. Oral administration of CHIR...
Impaired insulin signaling through GSK3 in insulin resistant skeletal muscle (Abstract). Diabetes 49, Suppl 1: A326, 2000.Brozinick JT, Misener EA, Ni B, Ryder JW: Impaired insulin signaling through GSK3 in insulin resistant skeletal muscle (Abstract). Diabe...
Insulin resistance, a harbinger of the metabolic syndrome, is a state of compromised hormonal response resulting from the dysregulation of a wide range of insulin-controlled cellular processes. However, how insulin affects cellular energy metabolism via long-term transcriptional regulation and whether boos...
GSK-3β is involved in the regulation of a wide range of cellular functions including differentiation, growth, proliferation motility, cell cycle progression, embryonic development, apoptosis, and insulin response. Dysregulation of GSK-3β expression leads to many pathological conditions, including ...
Human Primary Dermal Fibroblasts (ATCC PCS-201-012, called hDFA in this study) were cultured in DMEM:F12 HAM 1:1 v/v (Sigma D6421), 7.5 mM GlutaMAX-I (Thermo Fisher), 1× antibiotic–antimycotic (Thermo Fisher), 2% FBS (Thermo Fisher), 0.8 μM Insulin (MP Biomedicals ...
GSK-3β STAR ELISA Kit 说明书 Instruction Manual For GSK-3β STAR ELISA Kit Catalog # 17- 471 Sufficient reagents for 96 assays per kit Contents Page I. TEST PRINCIPLE 1 II. BACKGROUND 2 III. ASSAY SENSITIVITY, DETECTION LIMITS and SPECIES REACTIVITY 2 IV. STORAGE ...
Inhibition of Glycogen-Synthase Kinase-3 by Insulin-Mediated by Protein-Kinase-B Glycogen synthase kinase-3 (GSK3) is implicated in the regulation of several physiological processes, including the control of glycogen and protein synthes... DAE Cross,DR Alessi,P Cohen,... - 《Nature》 被引量:...
In vitro, RT‐PCR and western blotting were used to measure the expression of osteogenesis‐ and Wnt signalling‐related genes and proteins in bone marrow mesenchymal stromal cells (BMSCs) from rats with T2D (TBMSCs) after PBS, insulin and exenatide treatment. RT‐PCR was used to detect the...