有证据表明,GSK-3beta参与了AD至少两种病理过程。因此GSK-3beta的靶向抑制已成为AD中一个非常有吸引力的治疗方案。 在AD中,GSK-3beta影响J-分泌酶对淀粉样蛋白前体蛋白(APP)的裂解,从而促进淀粉样肽AE的产生,AE在细胞外空间积聚,并以老年斑的形式聚集;AE可以激活GSK-3E,导致Tau蛋白的过度磷酸化,Tau蛋白与微管...
有证据表明， GSK-3beta参与了AD至少两种病理过程。因此GSK-3beta的靶向抑制已成为AD中一个非常有吸引力的治疗方案。在AD中，GSK-3beta影响J-分泌酶对淀粉样蛋白前体蛋白(APP)的裂解，从而促进淀粉样肽AE的产生，AE在细胞外空间积聚，并以老年斑的形式聚集；AE可以激活GSK-3E，导致Tau蛋白的过度磷酸...
糖原合成酶激酶-3(GSK-3)是阿尔茨海默病(AD)发展过程中的关键分子。GSK-3β参与成对螺旋丝(PHF)-tau的形成,这是破坏神经元功能的神经原纤维缠结(NFT)沉积物的组成部分,也是AD神经退行性变的标志。 关键字:GSK-3 beta;GSK-3 beta蛋白;GSK3B蛋白;ACRO;百普赛斯; ...
Beta-amyloid (A beta) accumulation, one of the most important pathogenic traits of Alzheimer's disease (AD), has been reported to induce neurotoxicity in vitro as well as in vivo. Honokiol, isolated from the bark of Magnolia officinalis, has neuroprotective effects in different models of AD ...
Intracellular neurofibrillary tangles, one of the characteristic hallmarks of Alzheimer's disease (AD), are mainly composed of hyperphosphorylated tau. The abnormal tau phosphorylation seems to be related to altered activity of kinases such as glycogen synthase kinase-3 (GSK-3). Tau pathology is ...
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AD Instruments | ab biosciences | apohtech | Abeomics | alstem | am systems | avantor | ASAHI | AQIX | Aquatic Diagnostics | ViroStat | Valley Biomedical | Synaptic Systems | QED bioscience | quidel | panpath | ProQinase | peptides International | peninsula laboratories international | ...
Currently, no research on the application of SBT to the prevention and treatment of AD and senility is reported at home and abroad. The invention firstly discloses that SBT has the effect of increasing the p-GSK-3beta level, decreasing the GSK-3beta level, and protecting nerves, and thus ...
Alzheimer’s disease (AD) is a neurodegenerative disease that is the leading cause of age-related dementia. Currently, therapeutic agent delivery to the CNS is a valued approach for AD therapy. Unfortunately, the CNS penetration is greatly hampered by th
AD Instruments | ab biosciences | apohtech | Abeomics | alstem | am systems | avantor | ASAHI | AQIX | Aquatic Diagnostics | ViroStat | Valley Biomedical | Synaptic Systems | QED bioscience | quidel | panpath | ProQinase | peptides International | peninsula laboratories international | ...