有证据表明,GSK-3beta参与了AD至少两种病理过程。因此GSK-3beta的靶向抑制已成为AD中一个非常有吸引力的治疗方案。 在AD中,GSK-3beta影响J-分泌酶对淀粉样蛋白前体蛋白(APP)的裂解,从而促进淀粉样肽AE的产生,AE在细胞外空间积聚,并以老年斑的形式聚集;AE可以激活GSK-3E,导致Tau蛋白的过度磷酸化,Tau蛋白与微管...
因此GSK-3beta的靶向抑制已成为AD中一个非常有吸引力的治疗方案。在AD中，GSK-3beta影响J-分泌酶对淀粉样蛋白前体蛋白(APP)的裂解，从而促进淀粉样肽AE的产生，AE在细胞外空间积聚，并以老年斑的形式聚集；AE可以激活GSK-3E，导致Tau蛋白的过度磷酸化，Tau蛋白与微管解离，导致神经原纤维变性的发生。G...
Background Alzheimer's disease (AD) is the progressive brain disorder which degenerate brain cells connection and causes memory loss. Though, AD is irreversible, it is not impossible to arrest or slow down the progression of the disease. However, this would only be possible if the disease is ...
糖原合成酶激酶-3(GSK-3)是阿尔茨海默病(AD)发展过程中的关键分子。GSK-3β参与成对螺旋丝(PHF)-tau的形成,这是破坏神经元功能的神经原纤维缠结(NFT)沉积物的组成部分,也是AD神经退行性变的标志。 关键字:GSK-3 beta;GSK-3 beta蛋白;GSK3B蛋白;ACRO;百普赛斯; ...
GSK-3β, His•Tag®, Human, Recombinant, E. coli Recombinant, human GSK-3β fused at the N-terminus to a His•Tag® sequence and expressed in E. coli. A dual specificity kinase that plays important roles in insulin- and Wnt-mediated cellular signalings. In AD (Alzheimer’s disea...
AD Instruments | ab biosciences | apohtech | Abeomics | alstem | am systems | avantor | ASAHI | AQIX | Aquatic Diagnostics | ViroStat | Valley Biomedical | Synaptic Systems | QED bioscience | quidel | panpath | ProQinase | peptides International | peninsula laboratories international | ...
A number of clinical investigations have shown that depression is a moderate to high-risk factor for Alzheimer's Disease (AD) and 30-50% of depressive patients develop mild cognitive impairment and AD. Although a Chinese herbal formulae peony has significant effects on the treatment of depression...
Currently, no research on the application of SBT to the prevention and treatment of AD and senility is reported at home and abroad. The invention firstly discloses that SBT has the effect of increasing the p-GSK-3beta level, decreasing the GSK-3beta level, and protecting nerves, and thus ...
AD Instruments | ab biosciences | apohtech | Abeomics | alstem | am systems | avantor | ASAHI | AQIX | Aquatic Diagnostics | ViroStat | Valley Biomedical | Synaptic Systems | QED bioscience | quidel | panpath | ProQinase | peptides International | peninsula laboratories international | ...
Alzheimer’s disease (AD) is a neurodegenerative disease that is the leading cause of age-related dementia. Currently, therapeutic agent delivery to the CNS is a valued approach for AD therapy. Unfortunately, the CNS penetration is greatly hampered by th