Non small cell lung cancer (NSCLC)AktGSK-3 betabeta-CateninAstragaloside IV (AS-IV) is an active ingredient in Astragalus membranaceus and is involved in various biological processes, such as regulating the immune system, and counteracting inflammation and malignancy. The aim of this study was to...
Apoptosis Intracellular Kinases Cell Structure and Signaling Molecules Chemokine Receptor Intracellular Signaling Common gamma Chain Receptor Family EMT Induction Hedgehog Family IL-10 Family IL-17 Family Intracellular Kinases in the Akt Pathway Intracellular Signaling Molecules in Angiogenesis ...
Apoptosis Intracellular Kinases Cell Structure and Signaling Molecules Chemokine Receptor Intracellular Signaling Common gamma Chain Receptor Family EMT Induction Hedgehog Family IL-10 Family IL-17 Family Intracellular Kinases in the Akt Pathway Intracellular Signaling Molecules in Angiogenesis ...
GSK-3是PI3 kinase/Akt信号通路的关键下游蛋白,Akt可以磷酸化GSK-3α的Ser21和GSK-3β的Ser9,并抑制它们的酶活性。这样在饮食诱导胰岛素分泌的情况下,胰岛素诱导Akt磷酸化,随后GSK-3β被Akt所磷酸化抑制,导致糖原合成酶磷酸化水平下降,糖原合成酶活性升高,糖原合成增加,从而降低血糖。GSK-3β在能量代谢、体型发育...
中文名称:GSK3 beta Rabbit Monoclonal Antibody 英文名称:GSK3 beta Rabbit Monoclonal Antibody 有效期: 一年 产品类别: MAPK与PI3K/Akt通路 PI3K/Akt Signaling 产品编号 产品名称 产品包装 产品价格 AF1543 GSK3 beta Rabbit Monoclonal Antibody 50μl 询价 来源 用途 交叉反应性 分子量 Rabbit WB, IF, IHC,...
（3）敲低Notch1受体的糖尿病小鼠GSK-3alpha, GSK-3beta 和p-GSK-3beta蛋白的表达显著降低，Notch1受体胞内段与GSK-3beta的相互作用受到干扰，其机制主要与Wnt/beta-catenin、Akt/GSK-3beta和PKCbeta2信号通路相关。（4）敲低Notch1受体导致心肌细胞自噬水平显著被抑制，证实Notch1受体通过AMPK信号通路调节自噬。
Stabilization of Snail through AKT/GSK-3beta signaling pathway is required for TNF-alpha-induced epithelial-mesenchymal transition in prostate cancer PC3 cells 喜欢 0 阅读量: 80 作者:XF Wang,J Du,DY Chen,F Zhang,H Wang,HS Wang,B Zhou,R Fang,SH Cai ...
(1). GSK-3 is a ubiquitously expressed serine/threonine protein kinase that phosphorylates and inactivates glycogen synthase. GSK-3 is a critical downstream element of the PI3K/Akt cell survival pathway whose activity can be inhibited by Akt-mediated phosphorylation at...
兔抗GSK3 BETA多克隆抗体用于颈部降温通过PI3K/Akt/GSK-3β信号通路减轻心肺复苏后兔脑损伤及抑制凋亡的机制研究。 检测原理 双抗体夹心法测定标本中GSK3 BETA水平。用纯化的GSK3 BETA抗体包被微孔板,制成固相抗体,往包被单抗的微孔中依次加入GSK3 BETA,再与HRP标记的GSK3 BETA抗体结合,形成抗体-抗原-酶标抗体...
but functionally non-identical. GSK-3a is inhibited by phosphorylation at S21 by Akt and other kinases. GSK-3 alpha and GSK-3 beta share 85% amino acid identity. Dysregulated GSK-3 has been implicated in several diseases including type II diabetes, Alzheimer's disease, bipolar disorder, and ...