Non small cell lung cancer (NSCLC)AktGSK-3 betabeta-CateninAstragaloside IV (AS-IV) is an active ingredient in Astragalus membranaceus and is involved in various biological processes, such as regulating the immune system, and counteracting inflammation and malignancy. The aim of this study was to...
Cell Structure and Signaling Molecules Chemokine Receptor Intracellular Signaling Common gamma Chain Receptor Family EMT Induction Hedgehog Family IL-10 Family IL-17 Family Intracellular Kinases in the Akt Pathway Intracellular Signaling Molecules in Angiogenesis ...
Apoptosis Intracellular Kinases Cell Structure and Signaling Molecules Chemokine Receptor Intracellular Signaling Common gamma Chain Receptor Family EMT Induction Hedgehog Family IL-10 Family IL-17 Family Intracellular Kinases in the Akt Pathway Intracellular Signaling Molecules in Angiogenesis ...
兔抗GSK3 BETA多克隆抗体用于颈部降温通过PI3K/Akt/GSK-3β信号通路减轻心肺复苏后兔脑损伤及抑制凋亡的机制研究。 检测原理 双抗体夹心法测定标本中GSK3 BETA水平。用纯化的GSK3 BETA抗体包被微孔板,制成固相抗体,往包被单抗的微孔中依次加入GSK3 BETA,再与HRP标记的GSK3 BETA抗体结合,形成抗体-抗原-酶标抗体...
用于颈部降温通过PI3K/Akt/GSK-3β信号通路减轻心肺复苏后兔脑损伤及抑制凋亡的机制研究 研究PI3K/Akt/GSK3β信号通路在颈部降温的调节作用,初步探讨颈部降温的脑保护作用是否与PI3K/Akt及GSK3β的磷酸化有关。 方法:健康雄性新西兰家兔随机分为5组,采用4min室颤模型。按照复苏后4、9、24小时不同时间点再分别分成...
Stabilization of Snail through AKT/GSK-3beta signaling pathway is required for TNF-alpha-induced epithelial-mesenchymal transition in prostate cancer PC3 cells 喜欢 0 阅读量: 80 作者:XF Wang,J Du,DY Chen,F Zhang,H Wang,HS Wang,B Zhou,R Fang,SH Cai ...
(1). GSK-3 is a ubiquitously expressed serine/threonine protein kinase that phosphorylates and inactivates glycogen synthase. GSK-3 is a critical downstream element of the PI3K/Akt cell survival pathway whose activity can be inhibited by Akt-mediated phosphorylation at...
but functionally non-identical. GSK-3a is inhibited by phosphorylation at S21 by Akt and other kinases. GSK-3 alpha and GSK-3 beta share 85% amino acid identity. Dysregulated GSK-3 has been implicated in several diseases including type II diabetes, Alzheimer's disease, bipolar disorder, and...
GSK3 serves a central signaling role [14] in many regulatory processes through intersection with the PI3K, mTOR, PKB/AKT, WNT, and MAPK pathways [15]. As such, GSK3 is currently a target for drug discovery efforts in Alzheimer's disease, cancer, diabetes, multiple sclerosis, and others (...