综上所述,本研究应用生物信息学分析结合细胞实验,结果显示茯苓多糖可以通过抑制SQLE促进NLRP3/GSDMD细胞焦亡途径,从而延缓肝癌进展。 1. 王智槟, 郜文辉, 杨仁义, 等. 基于P53/xCT/GPX4通路探讨实脾消积方干预糖代谢异常肝癌细胞铁死亡...
Kang et al. found that deletion of glutathione-dependent lipid hydroperoxidase 4 (GPX4) increased GSDMD-N formation, proteolytic IL-1β (p17), caspase-1 maturation, and the activation of caspase-11 (p26) in BMDM following LPS electroporation or E. coli infection, and when cystatin-11 is abs...
Additionally, QBT reversed abnormal changes associated with ferroptosis and pyroptosis in the brains of VaD rats, concurrently up-regulating the Nrf2/xCT/GPX4 pathway and down-regulating the NLRP3/Caspase-1/GSDMD pathway to inhibit ferroptosis and pyroptosis in neuronal cells, thereby exerting a ...
抗氧化剂防御酶谷胱甘肽过氧化物酶4(Glutathione peroxidase,GPX4)能够负调控巨噬细胞焦亡,髓系细胞Gpx4基因缺失增加脂质过氧化依赖性Caspase激活和GSDMD剪切,引发细胞焦亡,促进小鼠脓毒症的发生。但是目前尚无有效的针对GSDMD在脓毒症炎症中的靶点药物。 发明内容 发明目的:本发明提供一种基于GSDMD蛋白RFWK基序的Ac-RF...
Quantitative analysis of: A Bax/Bcl-2; B Cytochrome C/GAPDH; C Cleaved-caspase 3/Caspase 3; D pRIPK3/tRIPK3; E pMLKL/tMLKL; F GPX4/GAPDH; G ACSL4/GAPDH; H NLRP3/GAPDH; I GSDMD-NT/GSDMD; n = 5–6 per group. All bar charts are expressed as mean...
抗氧化剂防御酶谷胱甘肽过氧化物酶4(Glutathione peroxidase,GPX4)能 够负调控巨噬细胞焦亡,髓系细胞Gpx4基因缺失增加脂质过氧化依赖性Caspase激活和 GSDMD剪切,引发细胞焦亡,促进小鼠脓毒症的发生。但是目前尚无有效的针对GSDMD在脓毒 症炎症中的靶点药物。 发明内容 [0003] 发明目的:本发明提供一种基于GSDMD蛋白RFWK...
Edaravone Dexborneol also inhibits pyroptosis by attenuating NF-魏B/NLRP3/GSDMD signaling, as well as ferroptosis by activating the Nrf-2/HO-1/GPX4 ... F Rahmati-Dehkordi,H Khanifar,A Zare-Hoseinabadi,... - 《Molecular Biology Reports》 被引量: 0发表: 2024年 Gasdermin D promotes influe...