Molecular Biological Features of Nottingham Histological Grade 3 Breast CancersIntroductionCancer biology dominates the behavior and prognosis of a tumor. Although Nottingham histological grade is a subjective pathological determination, it has been accepted as a surrogate model for cancer biology. As such,...
breast cancerECMmass spectrometryTN tumorsTumor extracellular matrix (ECM) plays a pivotal role in outcome of breast cancer (BC) patients. Overespression of 58 genes, encoding 43 structural ECM proteins, has been identified to determine a specific cluster of BC with accelerated metastatic potential ...
In early-stage breast cancer, where the use of systemic therapy has to be determined for every patient, the three main prognostic determinants used in routine practice are lymph node (LN) status, tumor size, and histological grade. The Nottingham (Elston-Ellis) modification of the Scarff-Bloom...
In grade 3, the cells are poorly differentiated and tend to grow faster than cells of other grades [[6], [7], [8]]. In general, a lower grade number indicates slower-growing cancer that is less likely to spread with better prognosis, while higher-grade breast cancer may grow and ...
Tumor development,histology and grade of breast cancers:prognosis and progression. Tabar L,Fagerberg G,Chen HH,et al. International Journal of Cancer . 1996Laszlo Tabar, Gunnar Fagerberg, HH Chen, SW Duffy, and A Gad. Tumour develop- ment, histology and grade of breast cancers: prognosis and...
MicroRNAs in the Tumor Microenvironment Chapter© 2020 Background Two of the most predictive measures of breast cancer (BC) patient mortality are tumor progression and immune infiltration [1,2,3]. By decoding and recognizing the underlying molecular patterns of invasive breast tumors, clinicians may...
Relationship of tumor grade to other pathologic features and to treatment outcome of patients with early stage breast carcinoma treated with breast-conservative... AJ Nixon,SJ Schnitt,R Gelman,... - 《Cancer》 被引量: 308发表: 1996年 Antitumor effects of ursolic acid in a mouse model of post...
The present pilot study constitutes a proof-of-principle in the use of a quantitative LC-MS/MS based proteomic method for the comparative analysis of representative low-grade breast primary tumor tissues with and without metastases and metastasis in lymph node relative to the nonmetastatic tumor typ...
Objective To study the value of tumor vein detected by susceptibility weighted imaging(SWI) in evaluation of glioma grade. Methods Thirty-nine cases of gliomas were confirmed pathologically, including 18 cases of low-grade gliomas(WHOⅠ-Ⅱgrade) and 21 cases of high-grade gliomas(WHO Ⅲ - Ⅳ ...
The patient had a remote history of tubal ligation and no known personal or family history of breast or gynecologic cancer. She initially presented with an abnormal Pap smear, and, on a subsequent endometrial curettage, detached fragments of high-grade adenocarcinoma were identified. Upon ...