Introduction The Golgi apparatus is a crucial organelle responsible for processing and packaging proteins and lipids in eukaryotic cells [1]. However, Golgi proteins themselves play particularly important roles within these functions. These proteins are involved in essential cellular processes such as glyco...
GM130 is also involved in the maintenance of the Golgi structure and plays a major role in the disassembly and reassembly of the Golgi apparatus during mitosis58, and is involved in the control of glycosylation, cell cycle progression and higher order cell functions such as cell polarization and...
Similarly, proper functioning of the Golgi apparatus is closely linked to cellular viability22, and its unique morphology, with tethered stacks of cisternae, is required for function. However, the Golgi apparatus can undergo disassembly and fragmentation into condensed, tubulovesicular punctate structures...
A majority of Golgi-related proteins were among the biotinylated proteins surrounding PAQR3 (Figure 2D). These analyses, therefore, further supported our previous findings that PAQR3 is predominantly localized in the Golgi apparatus that is the central sorting station in the endomembrane system and ...
Trans-Golgi apparatus membrane protein TVP23 homolog B (TVP23B) is a transmembrane protein conserved from yeast to humans. We found that TVP23B controls the homeostasis of Paneth cells and function of goblet cells, leading to a decrease in antimicrobial peptides and more penetrable mucus layer. ...
ACBD3. In GFP-expressing cells ACBD3 primarily condensed at the Golgi apparatus (Fig. 2a, upper), which is analogous to normal cells where ACBD3 typically co-localizes with a Golgi-resident protein Golga5 (Fig. S1A). However, in GFP-3A-expressing cells ACBD3 dispersed into the ...
S. et al. Correlative light-electron microscopy reveals the tubular-saccular ultrastructure of carriers operating between Golgi apparatus and plasma membrane. J. Cell Biol. 148, 45–58 (2000). 53. Brown, W. J. & Farquhar, M. G. Immunoperoxidase methods for the localization of antigens in...