The Golgi apparatus is a crucial organelle responsible for processing and packaging proteins and lipids in eukaryotic cells [1]. However, Golgi proteins themselves play particularly important roles within these functions. These proteins are involved in essential cellular processes such as glycosylation, li...
Nuclear PTEN safeguards pre-mRNA splicing to link Golgi apparatus for its tumor suppressive role Shao-Ming Shen, Yan Ji, Cheng Zhang, Shuang-Shu Dong, Shuo Yang, Zhong Xiong, Meng-Kai Ge, Yun Yu, Li Xia, Meng Guo, Jin-Ke Cheng, Jun-Ling Liu, Jian-Xiu Yu & Guo...
Similarly, proper functioning of the Golgi apparatus is closely linked to cellular viability22, and its unique morphology, with tethered stacks of cisternae, is required for function. However, the Golgi apparatus can undergo disassembly and fragmentation into condensed, tubulovesicular punctate structures...
Functionally important AGP glycans are synthesized in the Golgi apparatus, but the relationships among their glycosylation levels, processing, and functionalities are poorly understood. Here, we report the identification and functional characterization of two Golgi-localized exo-β-1,3-galactosidases from ...
A majority of Golgi-related proteins were among the biotinylated proteins surrounding PAQR3 (Figure 2D). These analyses, therefore, further supported our previous findings that PAQR3 is predominantly localized in the Golgi apparatus that is the central sorting station in the endomembrane system and ...
Trans-Golgi apparatus membrane protein TVP23 homolog B (TVP23B) is a transmembrane protein conserved from yeast to humans. We found that TVP23B controls the homeostasis of Paneth cells and function of goblet cells, leading to a decrease in antimicrobial peptides and more penetrable mucus layer. ...
ACBD3. In GFP-expressing cells ACBD3 primarily condensed at the Golgi apparatus (Fig. 2a, upper), which is analogous to normal cells where ACBD3 typically co-localizes with a Golgi-resident protein Golga5 (Fig. S1A). However, in GFP-3A-expressing cells ACBD3 dispersed into the ...
S. et al. Correlative light-electron microscopy reveals the tubular-saccular ultrastructure of carriers operating between Golgi apparatus and plasma membrane. J. Cell Biol. 148, 45–58 (2000). 53. Brown, W. J. & Farquhar, M. G. Immunoperoxidase methods for the localization of antigens in...