autophagyThe survival of any eukaryotic cell may have a unified theory i.e., energy production and clearance of unwanted organelles or pathogens which may be biological or non-biological. Survival of species over time depends not only on survival of cell but also on its ability to replicate ...
Here, we show that the deletion of GOLGA2, encoding a cis-Golgi protein, induces autophagy with Golgi disruption. The induction of autophagy leads to fibrosis along with the reduction of subcellular lipid storage (lipid droplets and lamellar bodies) by autophagy in the lung and liver. GOLGA2...
D Gozuacik,A Kimchi 摘要: Autophagy is characterized by sequestration of bulk cytoplasm and organelles in double or multimembrane autophagic vesicles, and their delivery to and subsequent degradation by the cell's own lysosomal system. Autophagy has multiple physiological functions in multicellular ...
Modulating glycosphingolipid metabolism and autophagy improves outcomes in pre-clinical models of myeloma bone disease Houfu Leng, Hanlin Zhang, Linsen Li, Shuhao Zhang, Yanping Wang, Selina J. Chavda, Daria Galas-Filipowicz, Hantao Lou, Adel Ersek, Emma V. Morris, Erdinc Sezgin...
Oliver, PhilippAndrea, HamannJörg, ServosAlexandra, WernerIna, KochHeinz, D. Osiewacz
Antidepressants regulate autophagy by targeting acid sphingomyelinasedoi:10.1038/s41380-018-0319-7Gulbins, AnneSchumacher, FabianBecker, Katrin AnneWilker, BarbaraSoddemann, MatthiasBoldrin, FrancescoMüller, Christian P.Edwards, Michael J.Goodman, Michael...
Herein, we review studies that face the autophagy process in tuberculosis patients as a component of the immune response of the human host against an intracellular microorganism such as Mtb. Interestingly, these findings might contribute to recognize new targets for the development of novel therapeutic...
Antidepressants regulate autophagy by targeting acid sphingomyelinasedoi:10.1038/s41380-018-0319-7NatureMolecular Psychiatry
TLR4 Activation Of Autophagy in Enterocytes Leads To Intestinal Inflammation And Reduced Restitution Via the Augophagosome Protein ATG16Introduction: Autophagy is an important process in the cellular response to stress and in innate immune signaling in diseases of intestinal inflammation such as Crohn's...
GOLGA2knockout miceGolgi disruptionAutophagyLung fibrosisLiver fibrosisAbstract Autophagy is a biological recycling process via the self-digestion of organelles, proteins, and lipids for energy-consuming differentiation and homeostasis. The Golgi serv... 查看全部>>...