glymphaticGlymphatic系统是大脑中一种独特的废物清除机制,主要通过脑脊液的流动清除代谢产物,维持脑内环境稳态,其功能与睡眠深度相关,并在神经退行性疾病的发生中起关键作用。以下从结构基础、运作机制、生理意义及与疾病关联四个方面展开说明。 Glymphatic系统的结构核心是由星形胶质细胞终足包裹脑血管...
Relationship between glymphatic system impairment, sleep disturbance and headache. Poor sleep can determine an impairment in the glymphatic flow which, in turn, leads to the accumulation of neuroexcitatory and pro-inflammatory chemicals involved in the development of headache. Headache itself can, directl...
胶质淋巴或glymphatic通路是最近在啮齿动物大脑中发现的液体清除通路。该通路促进脑脊液 (CSF) 沿动脉血管周围间隙流入大脑,然后流入由水通道蛋白 4 (AQP4) 水通道促进的脑间质。然后该通路将流量引导至静脉血管周围和神经周围空间,最终将溶质从神经纤维网清除到脑膜和颈部淋巴引流管中。在啮齿动物中,glymphatic 通路主要...
我们尚未发现一种能够在宏观尺度上评估非神经细胞类型的功能状态的神经成像模式,这也将促进一些新的非侵入性神经成像方法的开发。 原文网址:The Brain's Glymphatic System: Current Controversies - PubMed PMID:32423764 DOI: 10.1016/j.tins.2020.04.003
glymphatic system, sleep disorders, and Alzheimer’s disease. Conclusions. Expansion of perivascular spaces [Virchow–Robin] can be regarded as an early structural marker of both glymphatic dysfunction and neurodegenerative diseases, while sleep disorders can be seen as a functional marker (symptom) of...
Using diffusion tensor imaging analysis along the perivascular spaces (DTI-ALPS) to assess glymphatic function, we performed a longitudinal analysis of glymphatic function in ALS and compared it to a disorder in the motor neuron disease spectrum, primary lateral sclerosis (PLS). From a cohort of ...
The glymphatic movement of fluid through the brain removes metabolic waste1,2,3,4. Noninvasive 40 Hz stimulation promotes 40 Hz neural activity in multiple brain regions and attenuates pathology in mouse models of Alzheimer’s disease5,6,7,8. Here we show that multisensory gamma stimulation...
The glymphatic system is a network of perivascular spaces that promotes movement of cerebrospinal fluid (CSF) into the brain and clearance of metabolic waste. This fluid transport system is supported by the water channel aquaporin-4 (AQP4) localized to vascular endfeet of astrocytes. The glymphatic...
(BY INVITATION) Neurosurgery and the glymphatic system Per Kristian Eide1,2,3 Received: 2 May 2024 / Accepted: 5 June 2024 / Published online: 21 June 2024 © The Author(s) 2024 Abstract The discovery of the glymphatic system has fundamentally altered our comprehension of cerebrospinal ...
The glymphatic hypothesis proposes a mechanism for extravascular transport into and out of the brain of hydrophilic solutes unable to cross the blood–brain barrier. It suggests that there is a circulation of fluid carrying solutes inwards via periarteri