These physiological and pathological conditions are strong risk factors for AD. In conclusion, impaired glymphatic clearance is an important pathogenetic mechanism for AD.Iyawnna HazzardMaryann BatisteTianyu LuoCyrus CheungForshing LuiExploration of Neuroprotective Therapy...
To test whether glymphatic clearance is associated with multisensory 40 Hz-mediated amyloid clearance, we began by monitoring CSF dynamics. We infused a fluorescent tracer (ovalbumin–Alexa Fluor 647 (OVA-647), with a molecular mass of 45 kDa) to the cisterna magna of 6-month-old 5XFAD mi...
To test whether glymphatic clearance is associated with multisensory 40 Hz-mediated amyloid clearance, we began by monitoring CSF dynamics. We infused a fluorescent tracer (ovalbumin–Alexa Fluor 647 (OVA-647), with a molecular mass of 45 kDa) to the cisterna magna of 6-month-old 5XFAD mi...
Our findings identify locus coeruleus (LC)-induced NE oscillations as the key driver of slow vasomotion, which in turn facilitates glymphatic clearance during natural sleep. These insights have broad implications for understanding the components of restorative sleep, the functions of slow vasomotion, and...
Norepinephrine oscillations regulate glymphatic clearance during spleen. Nat Cardiovasc Res 4, 121 (2025). https://doi.org/10.1038/s44161-025-00616-2 Download citation Published04 February 2025 Issue DateFebruary 2025 DOIhttps://doi.org/10.1038/s44161-025-00616-2 Springer Nature Limited Access ...
When It Comes to Glymphatic Clearance, Not All Anesthetics, or Sleep Stages, Are Equal: The Clinical and Basic Neuroscience ImplicationsWhen It Comes to Glymphatic Clearance, Not All Anesthetics, or Sleep Stages, Are Equal: The Clinical and Basic Neuroscience Implicationsdoi:10.1097/01.NT....
Optic nerve diseasesPathogenesisdoi:10.1038/s41433-020-1008-8Peter WostynEye
are correlated with glymphatic clearance and neuroinflammation. Glial cells cannot be overlooked when considering the neuroinflammatory processes. Astrocytes are essential for the effective functioning of the glymphatic system and play a crucial role in the inflammatory responses in the central nervous system...
Glymphatic clearance impaired in a mouse model of tauopathy: captured using contrast-enhanced MRI[J]. Alzheimers Dement, 2015, 11:P107.doi:10.1016/j.jalz.2015.06.183. [7] Nakada T, Kwee IL, Igarashi H, et al. Aquaporin- 4 functionality and virchow-robin space water dynamics: physiological...
The brain glymphatic system is involved in the clearance of misfolding α-synuclein, the impaired glymphatic system may contribute to the progression of Parkinson’s disease (PD). We aimed to analyze the diffusion tensor image along the perivascular space (DTI-ALPS) and perivascular space (PVS) ...