which is thought to govern CSF influx. Leveraging a variety of imaging modalities to monitor multiple aspects of the glymphatic pathway, as well as genetic and molecular interventions, we found that gamma stimulation promoted the influx of CSF into the ...
which is thought to govern CSF influx. Leveraging a variety of imaging modalities to monitor multiple aspects of the glymphatic pathway, as well as genetic and molecular interventions, we found that gamma stimulation promoted the influx of CSF into the ...
Traumatic brain injury: Glymphatic pathway dysfunction after traumatic brain injury might promote tau aggregation.Nat Rev Neurol. 2014 Dec 16. doi: 10.1038/nrneurol.2014.245. [Epub ahead of print]doi:10.1038/nrneurol.2014.245Nature Reviews Neurology...
et al. Ketamine Improves the Glymphatic Pathway by Reducing the Pyroptosis of Hippocampal Astrocytes in the Chronic Unpredictable Mild Stress Model. Mol Neurobiol 61, 2049–2062 (2024). https://doi.org/10.1007/s12035-023-03669-1 Download citation Received02 May 2023 Accepted20 September 2023 ...
Impairment of Glymphatic Pathway Function Promotes Tau Pathology after Traumatic Brain Injury J. Neurosci., 34 (2014), pp. 16180-16193, 10.1523/JNEUROSCI.3020-14.2014 View in ScopusGoogle Scholar 3 K. Ishida, K. Yamada, R. Nishiyama, T. Hashimoto, I. Nishida, Y. Abe, M. Yasui, T. Iwa...
Glymphatic system is an emerging pathway of removing metabolic waste products and toxic solutes from the brain tissue. It is made of a network of perivascular spaces, filled in cerebrospinal and interstitial fluid, encompassing penetrating and pial vesse
The glymphatic hypothesis proposes that there is an extramural periarterial pathway (the dashed green line in Fig.5) for influx, not efflux, and tacitly assumes that the net fluid flow carrying this influx is fast enough to exclude efflux by the same route. However, the presence of free-flui...
This group previously discovered a brain-wide perivascular transport pathway for fluids and solutes that is contiguous with cerebrospinal fluid (CSF). These perivascular tunnels are created by astrocytes, a subtype of glial cells, and serve a pseudo-lymphatic function, hence the term glia-lymphatic ...
et al. Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injury. J. Neurosci. 34, 16180–16193 (2014). Article PubMed PubMed Central Google Scholar Plog, B. A. et al. Biomarkers of traumatic injury are transported from brain to blood via the glymphatic ...
(CSF) transferring along the perivascular space into the brain interstitium, facilitated by the aquaporin-4 water channels. The efficiency of CSF movement in the glymphatic pathway, known as glymphatic system functioning, is influenced by sleep-wake cycles [3,4]. The functioning of the glymphatic ...