Microbiology and ImmunologyDespite the fact that many reports deal with glycolysis in Lactococcus lactis, there is not much information on the regulation of uptake of glucose itself. The aim of the present work was to investigate the effect of the glucose level on its specific uptake rate. ...
Molecular Physiology of the Regulation of Hepatic Gluconeogenesis and Glycolysis Understanding the regulation of hepatic glucose metabolism had its foundation in the elucidation of several pathways, but recent advances have come from th... SJ Pilkis,DK Granner - 《Annu.rev.physiol》 被引量: 1986发表...
Breast cancer is the most common cancer in women and its incidence rates are rapidly increasing in China. Understanding the molecular mechanisms of breast cancer tumorigenesis enables the development of novel therapeutic strategies. SEC61G is a subunit o
feedback‐inhibited by its product, so the phosphorylation of glucose is inhibited if there is a buildup of glucose‐6‐ phosphate. In mammalian cells, the breakdown of glycogen is regulated by covalent modification of glycogen phosphorylase. This regulation reduces the rate of formation of glucose...
Organization of the plant cytosolic glycolytic pathway and its regulation by abiotic stresses in non photosynthetic tissues. glycolysisironmessenger RNAnutrient deficienciesoxygenphosphatesreviewsstressWe review here the structure and regulation of the plant cytosolic glycolytic pathway and... J Rivoal,S Dorio...
Apart from its glucose OXPHOS action, a form of HK called HKII can attach to voltage-dependent anion channels (VDACs) located on the outer mitochondrial membrane [43, 44]. To ensure that tumour cells entrap adequate glucose, this VDAC-HK interaction inhibits the negative feedback regulation of...
Point mutations that lock KRAS into the GTP-bound state occur with high frequency in pancreatic, colon, and non-small lung cancers. This prominence of KRAS as an important oncogenic driver renders urgent the need to decode its biological and biophysical vulnerabilities. For biological activity, ...
Numerous investigations have unveiled the molecular mechanisms through which m6A modification regulates tumor glycolysis and its pivotal role in this metabolic process. In this review, we provide a brief introduction to the regulation of m6A modification. Then, we systematically describe the effects of ...
Glucose 6-phosphate can also be oxidized to form ribose 5-phosphate and NADPH via the pentose phosphate pathway. Phosphofructokinase-1 (PFK-1) is the main point of regulation for controlling the rate of glycolysis. The activity of PFK-1 is regulated by various effectors having various signaling...
Esophageal squamous cell carcinoma (ESCC) is a common fatal malignant tumor of the digestive tract; however, its pathogenic mechanism is unknown and lacks specific molecular diagnosis and treatment. Therefore, it is particularly important to identify new tumor biomarkers to enhance the early diagnosis ...