[1] 《多肽药物制备工艺研究进展》[2] 《Designing a Dual GLP-1R/GIPR Agonist from Tirzepatide: Comparing Residues Between Tirzepatide, GLP-1, and GIP》[3] 《Kilogram-Scale GMP Manufacture of Tirzepatide Using a Hybrid SPPS/LPPS Approach with Continuous Manufacturing》文中数据及参数均由企业提...
GLP-1 agonist medications work bymimickingthis hormone. In medication terms, anagonistis amanufacturedsubstance that attaches to a cell receptor and causes the same action as the naturally occurring substance. In other words, GLP-1 medications bind to GLP receptors to trigger the effects (or roles...
[8] Merck steps into NASH space with early data for its GLP-1/glucagon receptor co-agonist. Retrieved June 14, 2023, from https://endpts.com/merck-steps-into-liver-disease-space-with-early-data-for-its-glp-1-glucagon-receptor-co-agonist/ [9] Can Novo Nordisk's blockbuster weight loss ...
[8]. Yue W, Li Y, Ou D, et al. The GLP-1 receptor agonist liraglutide protects against oxidized LDL-induced endothelial inflammation and dysfunction via KLF2. IUBMB Life. 2019 Sep;71(9):1347-1354. [9]. Di B, Li HW, L...
[2] Wharton, Sean et al. “Daily Oral GLP-1 Receptor Agonist Orforglipron for Adults with Obesity.” The New England journal of medicine vol. 389,10 (2023): 877-888. doi:10.1056/NEJMoa2302392 [3] Wilding, John P H et al. “Onc...
优点是突破产能瓶颈，更适合大规模连续生产，通过优化生物发酵过程和利用微生物高效的生物合成能力，能够进一步降低生产成本。资料来源：Drug Des Devel Ther. Lijing Wang，《Designing a Dual GLP-1R/GIPR Agonist from Tirzepatide: Comparing Residues Between Tirzepatide, GLP-1, and GIP》，X技术，国知局，...
GLP-1类药物开启新时代：实验室杂质研究保证产品质量 近日印发肥胖症诊疗指南（2024年版），重点提到减重药物的研发进展迅速，尤其是以胰高血糖素样肽-1受体激动剂（glucagon-likepeptide-1receptoragonist,GLP-1RA）为基础的新型减重药物不断问世。司美格鲁肽、利拉鲁肽、替尔泊肽等药物成为备受关注的“减肥神药”...
鉴于此，对于GLP-1受体激动剂的长期安全性和潜在的甲状腺癌风险进行深入研究变得尤为迫切。2024年4月，《英国医学杂志》（BMJ）杂志发表了一篇题为《Glucagon-like peptide 1 receptor agonist use and risk of thyroid cancer: Scandinavian cohort study》（《胰高血糖素样肽1受体激动剂的使用与甲状腺癌风险：斯堪的...
[10] Frias, J. P. Tirzepatide: a glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) dual agonist in development for the treatment of type 2 diabetes. Expert Rev Endocrinol Metab. 2020, 15, 379-394. ...