The continuously growing Human GLP-1R (Luc) HEK293 Reporter Cell (Cat. No.CHEK-ATF096) was stimulated with serial dilutions of Tirzepatide (a dual GLP-1R and GIPR agonist). Tirzepatide stimulated response demonstrates passage stabilization (fold induction and EC50) across passage 8-24. ●GIP...
, at post-conditioning attenuates the ability of alcohol to cause a reward-dependent memory consolidation as measured in the conditioned place preference model (Egecioglu et al., 2013c, Vallöf et al., 2016) providing some contradictory results regarding two different GLP-1 receptor agonist. ...
This reporter cell (Cat. No.CHEK-ATF128) was incubated with serial dilutions of human GLP-2R agonist. The EC50 of human GLP-2R agonist (Glepaglutide) was approximately 0.1281 nM. ●GLP-2R激动剂筛选应用案例-FOLD Bioactivity analysis of human GLP-2R agonist (FOLD). This reporter cell (...
This reporter cell (Cat. No.CHEK-ATF128) was incubated with serial dilutions of human GLP-2R agonist. The EC50 of human GLP-2R agonist (Glepaglutide) was approximately 0.1281 nM. ●GLP-2R激动剂筛选应用案例-FOLD Bioactivity ...
Semaglutideis the newest GLP-1Ragonist and was approved by the FDA as a once-weekly injection for the treatment of T2DM in late 2017. The peptide is chemically similar to liraglutide, with the inclusion of two structural modifications (Lau, Bloch, et al., 2015). ...
This reporter cell was incubated with serial dilutions of Tirzepatide (a dual GLP-1R and GIPR agonist). The max induction fold was approximately 328. ACROBiosystems百普赛斯全面助力抗体药物研发,在原有的靶点蛋白业务基础上推出了以:ADCC及ADCP功能验证用报告基因细胞系、靶点及通路研究、Cross-linking药物...
Glucagon‐like peptide-1 receptor agonistMortalityCardiovascular diseaseBackground Major prospective randomized clinical safety trials have demonstrated beneficial effects of treatment with glucagon-like peptide-1 receptor agonists (GLP-1RA) and sodium–glucose co-transporter-2 inhibitors (SGLT-2i) in people...
This reporter cell was incubated with serial dilutions of Retatrutide (a triple agonist peptide of GCGR, GIPR and GLP-1R). The max induction fold was approximately 79.93. 05重组蛋白产品列表 GLP-1R/GCGR重组蛋白产品列表,点击列表即可查看产品详情哦 GLP-1R、GCGR重组蛋白产品列表 06重组蛋白验证数据 ...
FGF21 compound has an FGF21 activity which is the same or substantially the same as the FGF21 activity of native FGF21, and wherein the GLP-1R agonist has a GLP-1R agonistic activity which is 9- to 531-fold reduced as compared to the GLP-1R agonistic activity of native GLP-1(7-36...
1. A combination comprising an FGF21 (fibroblast growth factor 21) compound and a GLP-1R (glucagon-like peptide-1 receptor) agonist, wherein the FGF21 compound has an FGF21 activity which is the same or substantially the same as the FGF21 activity of native FGF21 and is an FGF21 varian...