Glp-1 activity enhancerPROBLEM TO BE SOLVED: To provide a GLP-1 activity enhancer which is efficacious, and high in the safety, and also ingestible continuously. SOLUTION: This GLP-1 activity enhancer contains as an effective component an extract from a plant selected from among Salacia ...
[9] Shousha, S., Nakahara, K., Nasu, T., Sakamoto, T., Murakami, N. 2007. Effect of glucagon-like peptide-1 and -2 on regulation of food intake, body temperature and locomotor activity in the Japanese quail. Neurosci Lett 415:102-107. [10] Raun, K., von Voss, P., Knudsen,...
[72] Gault, V.A., Bhat, V.K., Irwin, N., Flatt, P.R. 2013. A novel glucagon-like peptide-1 (GLP- 1)/glucagon hybrid peptide with triple-acting agonist activity at glucose-dependent insulinotropic polypeptide, GLP-1, and glucagon receptors and therapeutic potential in high fat-fed mic...
[24] Mochida, T., Hira, T., Hara, H. 2010. The corn protein, zein hydrolysate, administered into the ileum attenuates hyperglycemia via its dual action on glucagon-like peptide-1 secretion and dipeptidyl peptidase-...
Glucagon like peptide-1 (GLP-1) is the second incretin identified in 1983. The first identified incretin was a gastric inhibitory peptide (GIP) with the activity of inhibiting the secretion of gastric acid, which was isolated from porcine small intestines [12]. Briefly, GLP-1 exists in the ...
[72] Gault, V.A., Bhat, V.K., Irwin, N., Flatt, P.R. 2013. A novel glucagon-like peptide-1 (GLP- 1)/glucagon hybrid peptide with triple-acting agonist activity at glucose-dependent insulinotropic polypeptide, GLP-1, and glucagon ...
根据安进科学家发表的论文《Chronic glucose-dependent insulinotropic polypeptide receptor(GIPR)agonism desensitizes adipocyte GIPR activity mimicking functional GIP antagonism》阐述的机制,长期的GIPR刺激可以导致GIPR脱敏,不再响应后续的GIP刺激,从而最终实质上发挥了拮抗作用,此外,可能的易内吞效应也会导致其事实上拮抗...
[9] Shousha, S., Nakahara, K., Nasu, T., Sakamoto, T., Murakami, N. 2007. Effect ofglucagon-like peptide-1 and -2 on regulation of food intake, body temperature andlocomotor activity in the Japanese quail. Neurosci Lett 415:102-107. ...
GLP-1 protects β-cells against apoptosis by enhancing the activity of an IGF-2/IGF1-receptor autocrine loop. Islets 2009; 1: 280-82.M. Cornu, B. Thorens, GLP-1 protects β-cells against apoptosis by enhancing the ac- tivity of an IGF-2/IGF1-receptor autocrine loop, Islets 1 (2009...
Description:A8SGLP-1是一种具有口服活性的GLP-1类似物多肽,其8位丙氨酸被丝氨酸取代,序列中含有31个氨基酸。A8SGLP-1可降低db/db小鼠的血糖而不影响其功能。 A8SGLP-1 is a GLP-1 analogue peptide with oral activity, with serine substituted alanine at position 8 and containing 31 amino acids in its ...