FUNCTION AND REGULATION OF GLP-1: AN EVOLUTIONARY APPROACHD, RudelLC, FriedmanE, DurkinJE, Kimble
Perturbation of endoplasmic reticulum (ER) homeostasis impairs insulin biosynthesis, β cell survival, and glucose homeostasis. We show that a murine model of diabetes is associated with the development of ER stress in β cells and that treatment with the GLP-1R agonist exendin-4 significantly reduc...
The data is suggestive that GLP-1 infusions have a more profound effect on larger infarcts. There is an upper limit to the timing of GLP-1 administration,which appears to beFinally, GLP-1 infusions also appear to decrease morbidity and mortality themselves, as evidenced by the reduction of ...
GLP-1 activates GLP-1 receptors (GLP-1r) on the β-cell to induce insulin secretion in a glucose-dependent manner. GLP-1 also inhibits α-cell secretion of glucagon. As few, if any, GLP-1r are expressed on α-cells, indirect regulation, via β- or δ-cell products has been thought ...
19.The method of claim 15, further comprising using an agent which enhances the half-life in vivo of the GLP-1 receptor binding compound. 20.The method of claim 15, wherein the patient is simultaneously infused with a combined glucose/GLP-1 receptor binding compound composition. ...
with the development of acute kidney injury.The present review aims to present the available data regarding the effects of GLP-1 receptor agonists on renal function,their use in subjects with chronic renal failure and their possible association with acute kidney injury.Based on the current evidence...
Physiological secretion of bile acids has previously been linked to the regulation of blood glucose. GLP-1 is an intestinal peptide hormone with important ... EP Rafferty,AR Wylie,KH Hand,... - 《Biological Chemistry》 被引量: 47发表: 2011年 [The significance of the bacterial steroid degradat...
Evolution of New Hormone Function: Loss and Gain of a Receptor The vertebrate proglucagon gene encodes three glucagon-like sequences (glucagon, glucagon-like peptide-1 [GLP-1], and glucagon-like peptide 2 [GLP-2]) that... DM Irwin,K Wong - 《Journal of Heredity》 被引量: 48发表: 2005...
Icovamenib improves beta cell function and insulin secretion, enhancing effectiveness of GLP-1 therapies in diabetes treatment.
GLP-1 is exclusively produced in approximately 50% of α-cells in lean mouse islets and 70% of α-cells in human islets, suggesting a paracrine α to β-cell signaling through the β-cell GLP-1 receptor. Additionally, we provide evidence that islet CCK expression is regulated by glucose, ...