Glp-1 activity enhancerPROBLEM TO BE SOLVED: To provide a GLP-1 activity enhancer which is efficacious, and high in the safety, and also ingestible continuously. SOLUTION: This GLP-1 activity enhancer contains as an effective component an extract from a plant selected from among Salacia ...
[72] Gault, V.A., Bhat, V.K., Irwin, N., Flatt, P.R. 2013. A novel glucagon-like peptide-1 (GLP- 1)/glucagon hybrid peptide with triple-acting agonist activity at glucose-dependent insulinotropic polypeptide, GLP-1, and glucagon ...
在体外已经证实了KATP通道活性在介导GLP-1释放中的重要性,同时也证实人L-细胞中存在KATP通道的Kir6.2/SUR1通道复合物[31],但KATP通道的Kir6.2/SUR1通道复合物是否在人体中介导GLP-1释放这一过程的作用还有待证实。 图2 L-细胞内...
[9] Shousha, S., Nakahara, K., Nasu, T., Sakamoto, T., Murakami, N. 2007. Effect of glucagon-like peptide-1 and -2 on regulation of food intake, body temperature and locomotor activity in the Japanese quail. Neurosci Lett 415:102-107. [10] Raun, K., von Voss, P., Knudsen,...
了解GLP-1影响体重的相关机制。 自胰高糖素样肽-1(GLP-1)被发现以来,已然成为一种“多面手”激素——其接二连三的代谢功能被人们发现,远远超出了作为肠促胰素的经典定义。GLP-1众多有益的作用使其受体激动剂逐渐成为更多新兴的治疗领域如脂肪肝、肥胖和神经退行性疾病等的冉冉之“星”药物,而GLP-1的减重作用...
[24] Mochida, T., Hira, T., Hara, H. 2010. The corn protein, zein hydrolysate, administered into the ileum attenuates hyperglycemia via its dual action on glucagon-like peptide-1 secretion and dipeptidyl peptidase-IV activity in rats. Endocrinology 151:3095-3104. ...
根据安进科学家发表的论文《Chronic glucose-dependent insulinotropic polypeptide receptor(GIPR)agonism desensitizes adipocyte GIPR activity mimicking functional GIP antagonism》阐述的机制，长期的GIPR刺激可以导致GIPR脱敏，不再响应后续的GIP刺激，从而最终实质上发挥了拮抗作用，此外，可能的易内吞效应也会导致其事实上...
度拉糖肽由两个GLP-1分子通过甘氨酸和丝氨酸为基础的间隔基在其C-端融合到人免疫球蛋白G4(IgG4)的Fc片段。 天然GLP-1的化学修饰对提高GLP-1RA治疗T2DM和肥胖的药理学价值至关重要。G…
根据安进科学家发表的论文《Chronic glucose-dependent insulinotropic polypeptide receptor(GIPR)agonism desensitizes adipocyte GIPR activity mimicking functional GIP antagonism》阐述的机制,长期的GIPR刺激可以导致GIPR脱敏,不再响应后续的GIP刺激,从而最终实质上发挥了拮抗作用,此外,可能的易内吞效应也会导致其事实上拮抗...
激素原转化酶可将胰高糖素原分子切成不同大小的肽段,包括含肠高血糖素相关胰多肽(GRPP; 氨基酸片段1 - 30)、胰高糖素(氨基酸片段33 - 61)、胃泌酸调节素(OXM;氨基酸片段 33 - 69)的肠高血糖素(氨基酸片段1 - 69)和含胰高糖素样肽1 (GLP-1;氨基酸片段 72-107/108)、胰高糖素样肽2 (GLP-2;氨基...