Mounjaro® (tirzepatide) Injection: The First and Only GIP and GLP-1 Receptor Agonist Approved for Type 2 Diabetes Mounjaro (tirzepatide) 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, and 15 mg per 0.5 mL injection, is a prescription medicine for adults with type 2 diabetes used along...
AMG 133 is an antibody–peptide conjugate. A fully human monoclonal GIPR-Ab is specifically conjugated at the E384C positions to a GLP-1 agonist peptide analogue using a linker, resulting in two GLP-1 agonist peptides per antibody molecule (Fig.1a). The average molecular weight of AMG 133 ...
* p = 0.0002 and ** p < 0.0001 using one-way ANOVA followed by Dunnett’s comparison versus the vehicle response. Data are representative of three (a) or two (b) independent experiments. c, Time course of plasma insulin concentrations in fasted, anesthetized Wistar rats treated ...
Real-world data for cardiorenal outcomes with GLP-1 RA are more limited, beyond the aforementioned EMPRISE study. Three-year outcomes from EMPRISE show that MI rates were similar between GLP-1 RA and empagliflozin, but that HHF was more common with GLP-1 RA, while stroke was less common [4...
GLP-1 RA: Glucagon-like peptide-1 receptor agonist HF: Heart failure HHF: HF hospitalisation IRR: Incidence rate ratio PCP: Primary care practitioner PMPY: Per member per year SGLT2i: Sodium–glucose transporter-2 inhibitor T2D: Type 2 diabetes ...
International Journal of Molecular Sciences Article GLP-1 Analogue Liraglutide Attenuates Mutant Huntingtin-Induced Neurotoxicity by Restoration of Neuronal Insulin Signaling Ching-Chi Chang 1,2,†, Tzu-Chin Lin 2,†, Hsiao-Li Ho 1, Chien-Yin Kuo 1, Hsin-Hua Li 1, Tatiana A. Korolenko 3,...