Previous studies have explored the effects of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) in reducing cardiovascular events in type 2 diabetes. Here we show that GLP-1 RAs are associated with lower risks of mortality, major cardiovascular event
[6] Nørgaard, Caroline Holm et al. “Treatment with glucagon-like peptide-1 receptor agonists and incidence of dementia: Data from pooled double-blind randomized controlled trials and nationwide disease and prescription registers.” Alzheimer's & dementia (New York, N. Y.) vol. 8,1 e12268...
GLP-1类制剂还为NASH的治疗带来了希望,一些针对NASH适应症的GLP-1类制剂已进入II/III期临床研究。目前的研究显示,GLP-1RA单药治疗可改善 NASH,但不改善肝纤维化;GLP-1/葡萄糖依赖性促胰岛素肽(GIP)双靶点可显著改善NASH;而 GLP-1/GIP/胰高血糖素受体(GCGR)三靶点治疗可使 90% 以上NASH患者实现肝脏脂肪正常...
The GLP-1 receptor agonists class comprises seven compounds/preparations with a similar mode of action. • GLP-1 receptor agonists differ with respect to pharmacokinetic properties, duration of action, and clinical effectiveness. • Plasma glucose is lowered by effects on insulin and glucagon secre...
[1] Hertzel C. Gerstein MD MSc FRCPC glp-1 receptor agonists(GLP-1RAs) in diabetes/for obesity evidence from large rcts . [2] Gerstein et al. dose response of efpeglenatide .Circulation 2023;147:1004 [3] Pan Q, Yuan M, Guo L. Exposure-Response Analysis of Cardiovascular Outcome Tri...
This cohort study compares glucagon-like peptide 1 receptor agonists (GLP-1RAs) with 7 non–GLP-1RA antidiabetics among drug-naive patients with type 2
2024年4月27日,中国医药教育协会与北京整合医学学会联合主办的第3届「和美天下」胰高糖素样肽-1(GLP-1)领域新进展学术交流会在上海、北京、广州、成都和武汉以线上和线下形式同时举行,国际著名糖尿病专家、曾获加拿大糖尿病协会终身成就奖及美国糖尿病协会(ADA)临床糖尿病研究杰出成就奖的Hertzel C.Gerstein 教授...
1. Introduction Glucagon-like peptide-1 (GLP-1) is an incretin hormone secreted in the gut in response to meal ingestion, which increases insulin secretion and inhibits glucagon production, targeting pancreatic β-cells 1. Thus, glucagon-like peptide-1 receptor agonists (GLP-1 RAs) both improve...
1. GLP-1与胰岛β细胞表面的GLP-1受体结合,激活GLP-1受体,并将信号传递下去,激活腺苷酸环化酶(AC),导致cAMP浓度增加; 2. cAMP激活PKA,对K + ATP通道的SUR1 亚基进行磷酸化,使SUR1 亚基无法与ADP 结合,保持β 细胞膜去极化,这就促进了胰岛素的分泌; ...
“But for all their promise, GLP-1 agonists have raised more questions than they have answered – a hallmark of a true breakthrough.”——Holden Thorp博士,《科学》期刊总编辑 今日,知名学术期刊《科…