Global view of human protein glycosylation pathways and functions Nat. Rev. Mol. Cell Biol., 21 (2020), pp. 729-749 CrossrefView in ScopusGoogle Scholar Spahn et al., 2016 P.N. Spahn, A.H. Hansen, H.G. Hansen, J. Arnsdorf, H.F. Kildegaard, N.E. Lewis A Markov chain model ...
norvegicus35 and/or human cells34,45. Interactions among Kac proteins of B. bassiana. Half of the identified Kac proteins varying in cell component, molecular function, biological process, KEGG pathway and subcellular localization were predicted to involve in 10 clusters of protein-protein ...
We leveraged a stable-isotope labeling strategy that enabled a global view of A2AAR structure and dynamics upon complex formation with an engineered Gs protein. This approach allowed us to map the impact of ternary complex formation on receptor dynamics at the protein-protein interface and at a ...
In this study, two groups of human plasma proteome at different age groups (old and young) were used to perform a comparison of global chemical modifications, as determined by tandem mass spectrometry (MS/MS) combined with non-limiting modification ident
The advancement of mass spectrometers as well as the development of new affinity purification tools has greatly expedited proteome-wide analysis of several post-translational modifications (e.g. phosphorylation, glycosylation, and acetylation). In contrast, large-scale profiling of lysine ubiquitination ...
For example, GNPS variable dereplication has detected compounds with different levels of glycosylation on various substrates. As MS/MS fragmentation preferentially results in peaks from glycan fragments, it is possible to detect sets of compounds with related glycans even when the substrates to which ...
CD16, a heavily glycosylated protein expressed on human immune cells, plays a crucial role in immune defense by linking antibody-antigen complexes with cellular effector functions. Glycosylation of CD16 decreases its affinity for IgG. MD simulations were run for CD16-IgG Fc complexes with or ...
3D-printed test tube and caps that form part of the test kit. Credit: Flinders University "Flinders NVI has had an office presence in our sister city Austin for over four years now with our local partner, Tech Ranch. I met Andrew from Endura Ventures as he was establishing PandemicTech an...
However, little effort has been made to obtain a general view of the gene expression and AS mechanisms of hypoxia in stem cell chondrogenic differentiation on a genome-wide scale. AS is known as a complicated regulatory process by which diverse mature RNA isoforms are generated from one pre-...
glycosylation. We demonstrate thatC. albicansfilamentation is not required for escape from host immune cells; instead, macrophage pyroptosis is driven by fungal cell-wall remodelling and exposure of glycosylated proteins in response to the macrophage phagosome. The capacity of killed, previously phagocyt...