Glycosylation of therapeutic proteins. Bio- Drugs. 2010;24:9‐21.Sola RJ, Griebenow K (2010) Glycosylation of therapeutic proteins. An effective strategy to optimize efficacy. BioDrugs 24(1):9-21Ricardo Solá,Kai Griebenow.Glycosylation of Therapeutic Proteins[J]. BioDrugs .2010(1)...
Sinclair AM, Elliott S: Glycoengineering: the effect of glycosylation on the properties of therapeutic proteins. J Pharm Sci 2005, 94:1626-1635.Sinclair, A.M. and S. Elliott, 2005., Glycoengineering: the effect of glycosylation on the properties of therapeutic proteins, Journal of Pharmaceutical...
Glycosylation is a critical quality attribute (CQA) of many therapeutic proteins, particularly monoclonal antibodies (mAbs), and is a major consideration in the approval of biosimilar biologics due to its effects to therapeutic efficacy. Glycosylation generates a distribution of glycoforms, resulting in ...
et al. Strategies for glycoengineering therapeutic proteins. Front. Chem. 10, 863118 (2022). Article CAS PubMed Central PubMed Google Scholar Chan, K. F. et al. Inactivation of GDP-fucose transporter gene (Slc35c1) in CHO cells by ZFNs, TALENs and CRISPR-Cas9 for production of fucose-...
Protein glycosylation in cancers and its potential therapeutic applications in neuroblastoma Abstract Glycosylation is the most complex post-translational modification of proteins. Altered glycans on the tumor- and host-cell surface and in the tumor microenvironment have been identified to mediate critical ...
2013. Comparison of the glycosylation of in vitro generated polyclonal human IgG and therapeutic ... I Ritamo,M Cloutier,L Valmu,... - 《Molecular Immunology》 被引量: 14发表: 2014年 N-Glycosylation of IgG and IgG-Like Recombinant Therapeutic Proteins: Why Is It Important and How Can We...
The majority of the therapeutic proteins are glycoproteins (monoclonal antibodies, blood proteins, growth factors, vaccines, fusion proteins).14For example erythropoietin (EPO), a common biotherapeutic protein, is highly glycosylated and may contain up to 50% glycans by weight, havin...
Define protein glycosylation. protein glycosylation synonyms, protein glycosylation pronunciation, protein glycosylation translation, English dictionary definition of protein glycosylation. n. The addition of saccharides to proteins or lipids to form a g
development of therapeutic agents. Generally, the cellularly expressed proteins can be identified using a comprehensive proteomic approach composed of LC/MS/MS of tryptic digests and data analysis17,18,19,20,21. The changes in a cell’s proteomic profile are associated with biological phenomena; ...
Glycosylation of therapeutic proteins: an effective strategy to optimize efficacy BioDrugs, 24 (2010), pp. 9-21 CrossrefView in ScopusGoogle Scholar 35 N. Sueoka Mitotic replication of deoxyribonucleic acid in Chlamydomonas reinhardtii Proc. Natl. Acad. Sci. U.S.A, 46 (1960), pp. 83-91 Cr...