Brain stem cells as the cell of origin in glioma. World J Stem Cells 2014;6:43-52.Modrek, A. S., Bayin, N. S., and Placantonakis, D. G. (2014). Brain stem cells as the cell of origin in glioma. World J. Stem Cells 6, 43-52. doi: 10.4252/wjsc.v6. i1.43Modrek AS,...
brain stem glioma - brain stem tumors being heterogeneous; patients with diffuse pontine tumors - usually present with short history (weeks) of signs or symptoms; diagnosis in typical cases - made via MRI scan, without biopsy; diffuse pontine tumors - significant portion of deaths due to childhoo...
CXCL12/CXCR4 signaling in malignant brain tumors: a potential pharmacological therapeutic target Regarding brain tumors, recent data demonstrate that glioma tumor stem-like cells promote tumor angiogenesis and vasculogenesis via the CXCL12/CXCR4 pathway. ... Mizuhiko,Terasaki,Yasuo,... - 《Brain Tumor...
Molecular subtypes, stem cells and heterogeneity: Implications for personalised therapy in glioma GlioblastomaGlioma stem cellsMesenchymalMolecular profilingPersonalised medicineProneuralWe discuss a number of recent developments that have led to new concepts ... A Morokoff,W Ng,A Gogos,... - 《Journal...
down-regulation of Nanog-targeted genes, which are associated with glioblastoma patient survival. Moreover, treatment of human glioma stem cells (hGSCs) with Lck-I, results in significant inhibition of self-renewal and tumor-sphere formation. The involvement of Lck in different levels of glioma ...
The immunosuppressive microenvironment in glioma induces immunotherapy resistance and is associated with poor prognosis. Glioma-associated mesenchymal stem cells (GA-MSCs) play an important role in the formation of the immunosuppressive microenvironment, but the mechanism is still not clear. ...
Glioma is the most common primary central nervous system (CNS) tumor in adults, which originates from neurogliocyte [1, 2], accounting for about 81 percent of malignant brain tumors [3]. Based on World Health Organization (WHO) classification, glioma has grades 1–4. The median survival of...
Glioblastoma (GBM) are the most common and aggressive tumors of human brain. Recent studies showed that human cytomegalovirus (HCMV) can induce malignant transformation of tumor cells to maintain stemness. Transcription factor 5 (ATF5) is an anti‐apoptotic protein that is highly expressed in mali...
These tumor cells have a stem cell-like phenotype and are suggested to be responsible for tumor growth, chemo- and radio-resistance as well as recurrence. However, functional evidence for migrating glioma cells having a stem cell-like phenotype is currently lacking. In the present study, the ...
Low grade gliomas are the most frequent brain tumors in children and encompass a spectrum of histologic entities which are currently assigned World Health Organisation grades I and II. They differ substantially from their adult counterparts in both their underlying genetic alterations and in the infreq...