We examined the potential of stem cell-like glioma cells (SCLGC) to support tumor angiogenesis. SCLGC isolated from human glioblastoma biopsy specimens and xenografts potently generated tumors when implanted into the brains of immunocompromised mice, whereas non-SCLGC tumo...
Despite advances in biology and therapeutic modalities, existence of highly tumorigenic glioma stem-like cells (GSCs) makes glioblastomas (GBMs) invincible.6-methyl adenosine (mA), one of the abundant mRNA modifications catalyzed by methyltransferase-like 3 and 14 (METTL3/14), influences various ...
Table 1.The expression and function of chemoattractant GPCRs in glioma stem like cells (GSLCs). GPCRsLigand (sources)Major functions on GSLCsReferences FPR1fMLF (bacteria); Mitochondrial peptides (ruptured cells) Annexin1(necrotic tumor cells and GSLCs)Angiogenesis; chemotaxis[21,60] ...
Brefeldin A and EHT-1864, agents that significantly inhibit VEGF secretion, decreased stem cell self-renewal, inhibited tumor growth, and increased the survival of mice allografted with S100β-v-erbB/p53−/− glioma stem-like cells. These agents also inhibit the expression of a hypoxia gene...
Glioma Tumor Stem-Like Cells Promote Tumor Angiogenesis and Vasculogenesis via Vascular Endothelial Growth Factor and Stromal-Derived Factor 1 Kerbel RS: Glioma tumor stem-like cells promote tumor angiogenesis and vasculogenesis via vascular endothelial growth factor and stromal- derived factor 1. ... ...
cancer stem cellglioblastomaGBM stem‐like cellsribosomal protein S6ribosomeGlioblastoma multiforme (GBM), a lethal brain tumor developing in the white matter of the adult brain, contains a small population of GBM stem cells (GSCs), which potentially cause chemotherapeutic resistance and tumor ...
Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor AB, Shi Q, McLendon RE, Bigner DD, Rich JN (2006) Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor. ... S Bao,Q Wu,S Sathornsumetee,... - 《Ca...
Here, we report that the invading edge and tumor core have two distinct types of glioma stem-like cells (GSCs) that resemble proneural (PN) and mesenchymal (MES) subtypes, respectively. Upon exposure to ionizing radiation (IR), GSCs, initially enriched for a CD133+ PN signature, transition ...
Human Glioma stemlike cells are better killed by YT-Indy NK cells.doi:10.1371/journal.pone.0153433.g001Bassoy Esen YoncaChiusolo ValentinaJacquemin GuillaumeRiccadonna CristinaR. PaulM. DenisPLOS ONE
网络胶质瘤干细胞 网络释义 1. 胶质瘤干细胞 ...别诊断和确定预后评估分子标志物必须解决的关键问题.胶质瘤干细胞(glioma stem cells)的发现及研究新进展为揭示胶质瘤发 … d.wanfangdata.com.cn|基于2个网页