Glioblastoma (GBM) is a high-grade glioma that despite a deep molecular understanding of its genomic mutational landscape, median overall survival is limited to 14.6 months1,2. While there is progress in the treatment of GBM by combining maximal surgical resection with radiotherapy, and concurrent ...
Among these, grade IV gliomas, also known as glioblastoma multiforme (GBM), exhibit the highest degree of growth aggressiveness2. Unfortunately, despite advances in diagnosis and drug therapy, glioblastoma remains incurable, with a median survival time of 15 months and a 5-year survival rate of ...
For the more aggressive form of glioma, glioblastoma, the survival rate with 5-year lifespan from the time of diagnosis is less than 5% (Stupp et al., 2005). Hence, glioma is considered as a malignant tumor and characterized by rapid growth, strong invasiveness, frequent postoperative relapse...
Perez Pausin J, et al. Long survival in a patient with high grade glioma. Reports of Practical Oncology and Radiotherapy 18 (Suppl. 1): S201-S202, Jun 2013. Available from: URL: http://dx..org/10.1016/j.rpor.2013.03.162 [abstract] - Spain...
classified as glioblastoma (World Health Organization grade IV glioma) [19, 20], which is difficult to treat; even with early diagnosis and aggressive surgery and radio−/chemotherapy, the median survival of these patients is 15 months [21], with a 5-year survival of just 5% [22, 23]....
Considerable Extension of Survival Achieved With Conventional Treatment in Grade 2 GliomaCaroline Helwick
Conclusion: GTR seems to be more effective than STR in achieving longer survival in elderly patients with high-grade glioma. 展开 关键词: elderly patients gross total resection high-grade glioma meta-analysis mortality subtotal resection DOI: 10.3389/fonc.2020.00151 年份: 2020 ...
Lower-grade gliomas are typically more diffuse, less proliferative, and associated with better survival compared to HGGs. Here, we use a new scalable scRNA-Seq method [17, 18] for massively parallel expression profiling of human HGG surgical specimens with single-cell resolution, focusing mainly ...
Progression free survival was similar with 0.84, 0.37, and 0.62 years respectively (P = 0.195). We conclude that these data suggest a benefit of high dose methotrexate when given prior to standard radiochemotherapy for some pediatric patients with high grade glioma.Wolff...
A major rate-limiting step in developing more effective immunotherapies for GBM is our inadequate understanding of the cellular complexity and the molecular heterogeneity of immune infiltrates in gliomas. Here, we report an integrated analysis of 201,986