gliomaepidemiologyWhy adults develop high-grade gliomas (HGG) is still unknown. These aggressive tumors may present in a number of ways, depending on such factors as growth rate and anatomic location. Whereas standard histopathological and epidemiological studies have helped us categorize patients with ...
Background: The optimal strategy for the management of high-grade glioma in the elderly (≥60.0 years) remains controversial, especially regarding the effects of surgical extent on survival outcomes. The purpose of this study was to compare gross total resection (GTR) with subtotal resection (STR...
high grade gliomamalignant oligodendrogliomasubtotal removal (STRBackground: Malignant glioma is themost common primary brain tumour inadults. More and more studies are focusedon the role of surgery in prolonged medianof survival and survival at two years. Thepurpose of this study is to add some...
from less aggressive forms to highly malignant tumors such as glioblastoma (GBM). GBM accounts for more than half of all malignant central nervous system (CNS) tumors, with a five-year survival rate of less than 10%1. The current standard-of-care for GBM consists ...
pedHGG-RTK2B (left); a glioma with diffuse infiltration of the midline (mesencephalon, basal ganglia and opticohypothalamic region) reaching the right temporal lobe. (right): a bithalamic tumor. c Kaplan–Meier plot displaying the overall survival (50% survival probability marked) of the two ...
anaplastic oligodendroglioma; BV, bevacizumab; CR, complete response; CT, chemotherapy; GB, glioblastoma; MG NOS, malignant glioma not otherwise specified; NA, not available; OS, overall survival; PFS, progression-free survival; PFS-6, progression-free survival at 6 months; PR, partial response;...
Pediatric high-grade glioma: aberrant epigenetics and kinase signaling define emerging therapeutic opportunities Article 05 June 2020 Introduction High-grade gliomas (HGGs) are central nervous system (CNS) tumors that occur in both children and adults, although bear distinct molecular features and neuro...
Later single-cell studies in glioma focused on lower-grade gliomas and the effects of IDH1 mutational status [15, 16]. Lower-grade gliomas are typically more diffuse, less proliferative, and associated with better survival compared to HGGs. Here, we use a new scalable scRNA-Seq method [17,...
Progression free survival was similar with 0.84, 0.37, and 0.62 years respectively (P = 0.195). We conclude that these data suggest a benefit of high dose methotrexate when given prior to standard radiochemotherapy for some pediatric patients with high grade glioma.Wolff...
In the included studies, sensitivity was defined as the proportion of patients with histopathologically confirmed TTP that presented as such with the modality of choice, or the true positive rate. Specificity was defined as the proportion of patients with histopathologically confirmed PsP that presented...