The present invention relates to the identification and use of biomarkers with clinical relevance to high grade gliomas (HGGs). In particular, the invention provides the identity of four genes, CHAF1B, PDLIM4, EDNRB and HJURP, whose expression, at the transcriptome and proteome levels, is ...
Gliomas are graded I–IV, according to the World Health Organization (WHO) system. WHO grading is based on the histological appearance, with treatment and prognosis highly dependent upon glioma grade. Grade I and II are considered low-grade and, although these patients are typically not cured, ...
However, in lower grade IDH-mutated tumours, MGMT methylation identifies a sub-population with a better prognosis irrespective of the applied treatment [18]. The determination of these markers is now part of routine practice; however, whether MGMT methylation status determination is carried out for ...
1. Low-grade gliomas (LGGs) constitute 15%-25% of all gliomas, with various biological features and clinical prognosis. 低级别胶质瘤占胶质瘤的15%~25%,生物学特性及临床预后相差较大。2. Objective To study the clinical value of 1H-magnetic resonance spectroscopy (1H-MRS) in differential ...
Prognosis is dismal with... A Bregy,AH Shah,MV Diaz,... - 《Expert Review of Anticancer Therapy》 被引量: 76发表: 2013年 Influence of Valproic Acid on Outcome of High-grade Gliomas in Children BACKGROUND: Chemotherapy has limited effects in the treatment of high-grade gliomas (HGGs). ...
8F–I). We also comprehensively investigated the distribution of SLC43A3 in different clinical subgroups, revealing a potential relationship between SLC43A3 expression and poor clinical prognosis (Supplementary Fig. 9A–M). To validate the findings, we assessed SLC43A3 expression in high-grade ...
Glioblastoma multiforme, a World Health Organization grade IV glioma, has a poor prognosis in humans despite current treatment options. Here, we present magnetic resonance imaging (MRI) data regarding the regression of aggressive rat F98 gliomas and human U87 glioma xenografts after treatment with ...
Clinical relevance of 1p and 19q deletion for patients with WHO grade 2 and 3 gliomas Purpose To assess the frequency of chromosomes 1p and 19q deletions in gliomas and to correlate 1p deletion with prognosis in patientswith grade 2 and grad... Fabio,M.,Iwamoto,... - Journal of Neuro-...
The clinical significance and function of HOTAIR in glioma remains unclear.We analyzed the clinical significance of HOTAIR in 3 different glioma cohorts with gene expression data, including correlation with tumor grade, prognosis, and molecular subtype. The function of HOTAIR in glioma was explored ...
(TAMs) being linked to high tumor grade and poor prognosis in many cancers, including glioma17,18,19,20. While the relative importance of the resident microglia and the blood-borne monocytes and macrophages in glioma tumorigenesis is under debate, there is substantial literature on the ...