With IMRT, dose escalation regarding the treatment of the regional tumor can be achieved with minimal increase in the dose to the surrounding normal brain tissue; alternative fractionation regimens, which may increase the biological effect, can also be employed. There have been several trials ...
Leptomeningeal tissue: a barrier against brain tumor cell invasion. dissemination in the central nervous system.The in vitro invasive behavior of human tumors of the central nervous system into human leptomeningeal tissue as ... Pedersen Paal-Henning,GJ Rucklidge,MØrk Sverre J.,... - 《Journal...
Glioblastoma is the most common primary malignant brain tumor in adults and is a challenging disease to treat. The current standard of care includes maximal safe surgical resection, followed by a combination of radiation and chemotherapy with temozolomide. Despite that, recurrence is quite common, and...
The RNA binding protein ADAR3 is expressed exclusively in the brain and reported to have elevated expression in tumors of patients suffering from glioblastoma compared to adjacent brain tissue. Yet, other studies have indicated that glioblastoma tumors exhibit hemizygous deletions of the genomic region ...
wild-type GBM from hereafter. On average, samples from recurrent tumors had less purity than primary cases (Fig.1dand Extended Data Fig.1c). All cell types found were represented in specimens from across all lobes of the brain, a spectrum of ages and both sexes (Extended Data Fig.1d–g...
The prognosis of patients affected by glioblastoma remains dismal despite many efforts have been devoted worldwide in research and therapeutic strategies. Reasons of our failure include the fact that the patient harboring a glioblastoma always has two problems inside the brain, the bulk tumor and the...
In addition, we demonstrate that the co-administration of the novel brain-penetrating CXCR4 antagonist, PRX177561, with bevacizumab or sunitinib inhibited tumor growth and reduced the inflammation. The combination of PRX177561 with bevacizumab resulted in a synergistic reduction of tumor growth with ...
Isolation of immune cells from brain hemispheres and blood In the first set of experiments naive, sham-operated and glioma bearing rats were sacrificed at day 8th, 14th, 21stafter cell inoculations. In further experiments rats implanted with C6 cells or medium were sacrificed at day 21stand perf...
Glioblastoma multiforme (GBM), the most aggressive and malignant glioma, has a poor prognosis. Although patients with GBM are treated with surgery, chemotherapy, and radiation therapy, GBM is highly resistant to treatment, making it difficult and expensive to treat. In this study, we analyzed the...
was assigned the class label “Abnormal Brain Growths,” as the majority of its nodes are associated with abnormal growths in the brain. DDrug repurposing or repositioning candidate identification High-influence node identification We calculated the degree, closeness, betweenness, eigenvector, and ...