Biodistribution analysis indicates a high accumulation of albumin NPs in brain-tumor, and PDT experiments showed a reduction in tumor growth after irradiation. On the other hand, nanorods (NRs) were used as a strategy to combine photothermal and photodynamic therapy. This nanosystem involves a ...
Glioblastoma multiforme (GBM) is characterized as a highly invasive, aggressive brain tumor1. Individuals with GBM face a poor prognosis, with few surviving past the 2-year mark1,2. A combination of chemotherapy, surgical resection, and radiotherapy is the gold standard for glioblastoma therapy, ...
The pore size diameter of each group was quantified using ImageJ (n = 2 to 20 photos per group, n = 13 to 170 measurements in each photo) and showed that enlarged and diverse pore sizes characterized the cell-laden bioink and brain tissue bearing the GB tumor...
Infiltrative growth is a major cause of high lethality of malignant brain tumors such as glioblastoma (GBM). We show here that GBM cells upregulate guidance receptor Plexin-B2 to gain invasiveness. Deletion of Plexin-B2 in GBM stem cells limited tumor spread and shifted invasion paths from axon ...
In vivo studies further conrmed that cryogels could be safely implanted into the brain. Although the implantation of clemastine loaded cryogels did not prevent the growth of the primary tumor, it reduced the amount of invasion tumor cells compared with the mice only resected the tumor. ...
On August 11th, 2011, I had a seizure. I had never had a seizure before. I had not been having headaches or any other suspicious symptoms. I was taken to the ER at Emory. An MRI revealed a tumor in the right temporal lobe of my brain. Doctors removed it and determined that it was...
Glioblastoma multiforme (GBM) is the most common and lethal primary brain tumor in adults; it has a spectrum of aberrantly aggressive phenotypes [1]. Although non-metastasizing, and the despite advances in treatments over the past decades, the extensive invasion of GBM limits patient survival to ...
Glioblastoma multiforme (GBM) is the most common and lethal primary brain tumor in adults; it has a spectrum of aberrantly aggressive phenotypes [1]. Although non-metastasizing, and the despite advances in treatments over the past decades, the extensive invasion of GBM limits patient survival to ...
Cells that had migrated and invaded Intracranial brain tumor xenografts, IHC, and hematoxylin–eosin staining Glioblastoma cells (5 × 105) were stereotactically im- planted into the brains of nude mice (n = 5 per group). The mice were monitored daily and euthanized when...
Revealing the role of SPP1+ macrophages in glioma prognosis and therapeutic targeting by investigating tumor-associated macrophage landscape in grade 2 and 3 gliomas Wenshu Tang Cario W. S. Lo Brian H. Y. Chung Cell & Bioscience (2024) MIF contribution to progressive brain diseases Agata Ma...