Surgery is most often the first part of the treatment plan. Aneurosurgeon, a surgeon who specializes in operating on the brain, tries to remove as much of the tumor as possible. Because glioblastomas often develop in healthy brain tissue, the neurosurgeon may not be able to remove all of t...
Binary masks were manually drawn over each image stack to select the tumor volume and corresponding regions in the healthy brain hemispheres for analysis. Care was taken that only well-resolved regions with minimal blurring were incorporated in the control datasets. This comprised the inner parts of...
S2)13,17. To strengthen further the validity of targeting NF-κB and gap junction in GB therapy, we hypothesized that a) GB cells should express higher levels of components of the NF-κB signalling machinery and gap junction-forming connexin proteins than healthy brain and b) there should be...
There are also studies that report multiple PyVs in GB tissues. Martini et al. detected SV40 LT antigen coding sequences in 10/30 (33%) GB samples but not in the 13 healthy control brain tissues using southern blotting and hybridisation. The authors also detected BKV DNA in 28/30 (93%)...
Therefore, it is of paramount importance to develop therapies that would affect the whole population of GBM cells, without causing off-target effects in healthy brain and surrounding tissues. Such measures must be taken to elicit a strong and widespread anti-tumour response and ...
Glioblastoma is the most aggressive primary brain tumor with a poor prognosis. The 2021 WHO CNS5 classification has further stressed the importance of mole
The findings demonstrated that KPNB1 was upregulated in glioma tissues compared to non-tumor brain tissues (Fig. 1H and I). Therefore, our data demonstrated that KPNB1 was upregulated in glioma tissues compared to healthy tissues, with high KPNB1 expression levels associated with poor prognosis ...
In particular, gelatinases MMP-2 and MMP-9 are expressed by glioma cells in human brain-tissue samples. However, it has been reported that it is the endothelial cells forming the connective framework for solid tumors that express MMP-2 and MMP-9, which, in turn, could be confiscated by ...
(Supplementary Table1). Western blot analysis revealed increased FMRP expression in GSCs compared to healthy neural stem cells isolated from human adult olfactory bulb (NSCs) and fetal brain (HPNC10), two cell types with a basal expression of FMRP [55] (Fig.1Cand Fig.S1B). Importantly, ...
(c) Comparable amounts of total proteins extracted from GBMs, astrocytomas and healthy brain were separated by sodium dodecyl sulfate– polyacrylamide gel electrophoresis, sample numbers are shown at the top. After blotting to a membrane, the samples were analyzed by immunoblotting for the ...